BAIT
SLC9A1
AW554487, Apnh, Nhe1, swe, RP23-32C12.6
solute carrier family 9 (sodium/hydrogen exchanger), member 1
GO Process (33)
GO Function (3)
GO Component (18)
Gene Ontology Biological Process
- cardiac muscle cell differentiation [IMP]
- cellular response to acidic pH [ISO]
- cellular response to epinephrine stimulus [ISO]
- cellular response to hypoxia [ISO]
- cellular response to insulin stimulus [ISO]
- cellular sodium ion homeostasis [ISO]
- embryo development [IMP]
- hydrogen ion transmembrane transport [IMP, ISO]
- negative regulation of apoptotic process [ISO]
- neuron death [ISO]
- positive regulation of NFAT protein import into nucleus [ISO]
- positive regulation of action potential [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of calcineurin-NFAT signaling cascade [ISO]
- positive regulation of calcium:sodium antiporter activity [ISO]
- positive regulation of cardiac muscle hypertrophy [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of intracellular signal transduction [ISO]
- positive regulation of mitochondrial membrane permeability [ISO]
- positive regulation of the force of heart contraction [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of cardiac muscle contraction by calcium ion signaling [ISO]
- regulation of intracellular pH [ISO]
- regulation of pH [IDA, IMP, ISO]
- regulation of sensory perception of pain [ISO]
- regulation of the force of heart contraction [ISO]
- regulation of the force of heart contraction by cardiac conduction [ISO]
- response to acidic pH [IMP, ISO]
- response to muscle stretch [ISO]
- response to organic cyclic compound [ISO]
- sodium ion import across plasma membrane [ISO]
- sodium ion transmembrane transport [IMP]
- sodium ion transport [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- T-tubule [ISO]
- apical plasma membrane [IDA]
- basolateral plasma membrane [ISO, TAS]
- cation-transporting ATPase complex [ISO]
- cell surface [ISO]
- cytoplasm [ISO]
- endoplasmic reticulum [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- integral component of plasma membrane [ISO]
- intercalated disc [ISO]
- membrane [IDA]
- membrane raft [ISO]
- mitochondrion [ISO]
- nucleoplasm [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [ISO]
- sarcolemma [ISO]
Mus musculus
PREY
ARRB1
1200006I17Rik, AW208571, G430100A01Rik
arrestin, beta 1
GO Process (34)
GO Function (19)
GO Component (12)
Gene Ontology Biological Process
- G-protein coupled receptor internalization [ISO]
- G-protein coupled receptor signaling pathway [ISO]
- activation of MAPK activity [ISO]
- endocytosis [ISO]
- follicle-stimulating hormone signaling pathway [ISO]
- negative regulation of ERK1 and ERK2 cascade [ISO]
- negative regulation of GTPase activity [ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of interleukin-6 production [ISO]
- negative regulation of interleukin-8 production [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of protein ubiquitination [ISO]
- phototransduction [IMP]
- positive regulation of ERK1 and ERK2 cascade [IMP, ISO]
- positive regulation of GTPase activity [ISO]
- positive regulation of Rho protein signal transduction [ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of histone H4 acetylation [ISO]
- positive regulation of histone acetylation [ISO]
- positive regulation of insulin secretion involved in cellular response to glucose stimulus [IMP]
- positive regulation of peptidyl-serine phosphorylation [IMP]
- positive regulation of protein binding [IMP]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of protein ubiquitination [ISO]
- positive regulation of receptor internalization [ISO]
- positive regulation of smooth muscle cell apoptotic process [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein ubiquitination [ISO]
- receptor-mediated endocytosis [ISO]
- regulation of G-protein coupled receptor protein signaling pathway [IMP, ISO]
- stress fiber assembly [ISO]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- AP-2 adaptor complex binding [ISO]
- GTPase activator activity [ISO]
- V2 vasopressin receptor binding [ISO]
- alpha-1A adrenergic receptor binding [ISO]
- alpha-1B adrenergic receptor binding [ISO]
- angiotensin receptor binding [ISO]
- clathrin adaptor activity [ISO]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IMP]
- estrogen receptor binding [ISO]
- follicle-stimulating hormone receptor binding [ISO]
- insulin-like growth factor receptor binding [ISO]
- ion channel binding [ISO]
- mitogen-activated protein kinase kinase binding [IDA]
- phosphoprotein binding [ISO]
- protein binding [IPI]
- protein phosphorylated amino acid binding [ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- ubiquitin protein ligase binding [ISO]
- AP-2 adaptor complex binding [ISO]
- GTPase activator activity [ISO]
- V2 vasopressin receptor binding [ISO]
- alpha-1A adrenergic receptor binding [ISO]
- alpha-1B adrenergic receptor binding [ISO]
- angiotensin receptor binding [ISO]
- clathrin adaptor activity [ISO]
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IMP]
- estrogen receptor binding [ISO]
- follicle-stimulating hormone receptor binding [ISO]
- insulin-like growth factor receptor binding [ISO]
- ion channel binding [ISO]
- mitogen-activated protein kinase kinase binding [IDA]
- phosphoprotein binding [ISO]
- protein binding [IPI]
- protein phosphorylated amino acid binding [ISO]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.792 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ARRB1 SLC9A1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 569133 |
Curated By
- BioGRID