CACNA1C
Gene Ontology Biological Process
- adult walking behavior [IGI]
- calcium ion import [IBA, ISO]
- calcium ion transmembrane transport [IMP]
- calcium ion transport [IDA, IMP, ISO]
- calcium ion-dependent exocytosis [IMP]
- cellular calcium ion homeostasis [IMP]
- glucose homeostasis [IMP]
- growth hormone secretion [IDA]
- insulin secretion [IMP]
- membrane depolarization during action potential [IBA]
- positive regulation of cytosolic calcium ion concentration [ISO]
- regulation of blood pressure [IMP]
- regulation of ion transmembrane transport [IMP]
- regulation of organ growth [IMP]
- regulation of vasoconstriction [IMP]
- smooth muscle contraction [IMP]
- smooth muscle contraction involved in micturition [IMP]
- synaptic transmission [IMP]
- visual learning [IMP]
Gene Ontology Molecular Function- alpha-actinin binding [ISO]
- calmodulin binding [ISO]
- enzyme binding [IPI]
- high voltage-gated calcium channel activity [IBA, ISO]
- ion channel binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein phosphatase 2A binding [ISO]
- voltage-gated calcium channel activity [IDA, IMP, ISO, TAS]
- alpha-actinin binding [ISO]
- calmodulin binding [ISO]
- enzyme binding [IPI]
- high voltage-gated calcium channel activity [IBA, ISO]
- ion channel binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein phosphatase 2A binding [ISO]
- voltage-gated calcium channel activity [IDA, IMP, ISO, TAS]
Gene Ontology Cellular Component
- T-tubule [IDA, ISO, TAS]
- Z disc [IDA, ISO]
- caveolar macromolecular signaling complex [IDA]
- cell [IMP]
- cytoplasm [ISO]
- cytosol [ISO]
- dendrite [ISO]
- dendritic shaft [IDA]
- integral component of membrane [ISO]
- membrane [IDA, ISO]
- neuronal cell body [IDA, ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [ISO]
- protein complex [ISO]
- sarcolemma [ISO]
- voltage-gated calcium channel complex [ISO, TAS]
CACNB3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Quantitative Score
- 0.92 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CACNA1C CACNB3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID