RAG1
Gene Ontology Biological Process
- B cell differentiation [IDA, IMP, ISO]
- DNA recombination [TAS]
- T cell differentiation in thymus [IMP, ISO]
- T cell homeostasis [IGI]
- V(D)J recombination [IGI, IMP, ISO]
- adaptive immune response [IMP]
- death [IMP]
- histone monoubiquitination [IDA, ISO]
- negative regulation of T cell apoptotic process [IGI]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of thymocyte apoptotic process [IMP]
- nucleic acid phosphodiester bond hydrolysis [IMP, ISO]
- pre-B cell allelic exclusion [IMP, ISO]
- protein autoubiquitination [IDA, ISO]
- regulation of T cell differentiation [IGI]
- thymus development [IGI]
Gene Ontology Molecular Function- endonuclease activity [IMP, ISO]
- histone binding [IDA, ISO]
- metal ion binding [IMP, ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA, ISO]
- sequence-specific DNA binding [IDA, IMP, ISO]
- ubiquitin protein ligase activity [IDA, ISO]
- ubiquitin-protein transferase activity [IDA, ISO]
- zinc ion binding [IDA, ISO]
- endonuclease activity [IMP, ISO]
- histone binding [IDA, ISO]
- metal ion binding [IMP, ISO]
- protein binding [IPI]
- protein homodimerization activity [IDA, ISO]
- sequence-specific DNA binding [IDA, IMP, ISO]
- ubiquitin protein ligase activity [IDA, ISO]
- ubiquitin-protein transferase activity [IDA, ISO]
- zinc ion binding [IDA, ISO]
KPNA2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell [IDA]
- cytoplasm [ISO]
- intracellular [IDA]
- membrane [ISO]
- nucleoplasm [ISO]
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Quantitative Score
- 0.697 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RAG1 KPNA2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID