RXRG
Gene Ontology Biological Process
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [IDA]
- protein homotetramerization [IDA]
- regulation of myelination [ISO]
- retinoic acid receptor signaling pathway [IDA]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function
NR1H2
Gene Ontology Biological Process
- cellular lipid metabolic process [IDA]
- cholesterol homeostasis [IDA]
- intracellular receptor signaling pathway [IDA]
- lipid homeostasis [IMP]
- negative regulation of cholesterol storage [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of lipid transport [ISO]
- negative regulation of pinocytosis [ISO]
- negative regulation of proteolysis [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of cellular protein metabolic process [ISO]
- positive regulation of cholesterol efflux [IDA, IGI, ISO]
- positive regulation of cholesterol transport [ISO]
- positive regulation of fatty acid biosynthetic process [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of high-density lipoprotein particle assembly [IDA]
- positive regulation of lipid storage [IMP]
- positive regulation of lipoprotein lipase activity [ISO]
- positive regulation of pancreatic juice secretion [IMP]
- positive regulation of secretion of lysosomal enzymes [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of triglyceride biosynthetic process [ISO]
- regulation of cholesterol homeostasis [IMP]
- regulation of transcription from RNA polymerase II promoter [IGI]
- regulation of transcription, DNA-templated [IDA]
- retinoic acid receptor signaling pathway [ISO]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- ATPase binding [ISO]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- apolipoprotein A-I receptor binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- protein binding [IPI]
- retinoid X receptor binding [IDA, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, IGI]
- sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity [ISO]
- ATPase binding [ISO]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- apolipoprotein A-I receptor binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- protein binding [IPI]
- retinoid X receptor binding [IDA, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, IGI]
- sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity [ISO]
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Quantitative Score
- 0.996 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RXRG NR1H2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID