RXRG
Gene Ontology Biological Process
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [IDA]
- protein homotetramerization [IDA]
- regulation of myelination [ISO]
- retinoic acid receptor signaling pathway [IDA]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function
NR1H2
Gene Ontology Biological Process
- cellular lipid metabolic process [IDA]
- cholesterol homeostasis [IDA]
- intracellular receptor signaling pathway [IDA]
- lipid homeostasis [IMP]
- negative regulation of cholesterol storage [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of lipid transport [ISO]
- negative regulation of pinocytosis [ISO]
- negative regulation of proteolysis [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of cellular protein metabolic process [ISO]
- positive regulation of cholesterol efflux [IDA, IGI, ISO]
- positive regulation of cholesterol transport [ISO]
- positive regulation of fatty acid biosynthetic process [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of high-density lipoprotein particle assembly [IDA]
- positive regulation of lipid storage [IMP]
- positive regulation of lipoprotein lipase activity [ISO]
- positive regulation of pancreatic juice secretion [IMP]
- positive regulation of secretion of lysosomal enzymes [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of triglyceride biosynthetic process [ISO]
- regulation of cholesterol homeostasis [IMP]
- regulation of transcription from RNA polymerase II promoter [IGI]
- regulation of transcription, DNA-templated [IDA]
- retinoic acid receptor signaling pathway [ISO]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- ATPase binding [ISO]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- apolipoprotein A-I receptor binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- protein binding [IPI]
- retinoid X receptor binding [IDA, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, IGI]
- sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity [ISO]
- ATPase binding [ISO]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- apolipoprotein A-I receptor binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- protein binding [IPI]
- retinoid X receptor binding [IDA, ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, IGI]
- sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity [ISO]
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
An atlas of combinatorial transcriptional regulation in mouse and man.
Combinatorial interactions among transcription factors are critical to directing tissue-specific gene expression. To build a global atlas of these combinations, we have screened for physical interactions among the majority of human and mouse DNA-binding transcription factors (TFs). The complete networks contain 762 human and 877 mouse interactions. Analysis of the networks reveals that highly connected TFs are broadly expressed across ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RXRG NR1H2 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.996 | BioGRID | 2683168 |
Curated By
- BioGRID