BAIT
DAB2IP
2310011D08Rik, AI480459, Aip1, mKIAA1743, RP23-4L24.1
disabled 2 interacting protein
GO Process (64)
GO Function (21)
GO Component (12)
Gene Ontology Biological Process
- I-kappaB phosphorylation [IMP]
- activation of JUN kinase activity [ISO]
- activation of MAPKKK activity [ISO]
- cell motility involved in cerebral cortex radial glia guided migration [IMP]
- cellular protein catabolic process [ISO]
- cellular response to epidermal growth factor stimulus [ISO]
- cellular response to interleukin-1 [IDA, ISO]
- cellular response to lipopolysaccharide [IDA, ISO]
- cellular response to tumor necrosis factor [IMP, ISO]
- cellular response to vascular endothelial growth factor stimulus [IDA, ISO]
- extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [IMP]
- layer formation in cerebral cortex [IMP]
- negative regulation of ERK1 and ERK2 cascade [ISO]
- negative regulation of G0 to G1 transition [ISO]
- negative regulation of GTPase activity [IMP]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- negative regulation of MAP kinase activity [ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of Ras GTPase activity [ISO]
- negative regulation of Ras protein signal transduction [IBA, ISO]
- negative regulation of angiogenesis [IMP, ISO]
- negative regulation of canonical Wnt signaling pathway [ISO]
- negative regulation of catenin import into nucleus [IMP]
- negative regulation of cell growth [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of cyclin catabolic process [ISO]
- negative regulation of endothelial cell migration [IMP, ISO]
- negative regulation of epidermal growth factor receptor signaling pathway [ISO]
- negative regulation of epithelial cell migration [ISO]
- negative regulation of epithelial cell proliferation [ISO]
- negative regulation of epithelial to mesenchymal transition [ISO]
- negative regulation of fibroblast proliferation [IMP]
- negative regulation of phosphatidylinositol 3-kinase activity [ISO]
- negative regulation of phosphatidylinositol 3-kinase signaling [ISO]
- negative regulation of protein phosphorylation [IMP, ISO]
- negative regulation of protein serine/threonine kinase activity [IMP, ISO]
- negative regulation of toll-like receptor 4 signaling pathway [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- negative regulation of vascular endothelial growth factor receptor signaling pathway [IMP, ISO]
- negative regulation of vascular endothelial growth factor signaling pathway [IDA]
- neuron projection morphogenesis [IMP]
- positive regulation of JNK cascade [ISO]
- positive regulation of JUN kinase activity [IMP, ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of Ras GTPase activity [IBA, ISO]
- positive regulation of apoptotic process [IMP, ISO]
- positive regulation of apoptotic signaling pathway [ISO]
- positive regulation of cell cycle arrest [ISO]
- positive regulation of dendrite development [IMP]
- positive regulation of neuron migration [IMP]
- positive regulation of neuron projection development [IMP]
- positive regulation of proteasomal protein catabolic process [ISO]
- positive regulation of protein catabolic process [IMP]
- positive regulation of protein serine/threonine kinase activity [IMP, ISO]
- positive regulation of synapse maturation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of ARF GTPase activity [IMP]
- regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- regulation of p38MAPK cascade [IMP]
- regulation of protein complex assembly [IMP, ISO]
- tube formation [IMP, ISO]
- vascular endothelial growth factor receptor-2 signaling pathway [IMP]
Gene Ontology Molecular Function- 14-3-3 protein binding [ISO]
- Ras GTPase activator activity [IBA, ISO]
- SH3 domain binding [ISO]
- Toll-like receptor 4 binding [IMP]
- death receptor binding [ISO]
- identical protein binding [ISO]
- kinase binding [ISO]
- mitogen-activated protein kinase kinase binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- phosphatidylinositol 3-kinase regulatory subunit binding [ISO]
- phosphatidylinositol-3-phosphate binding [ISO]
- phosphatidylinositol-4-phosphate binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein homodimerization activity [ISO]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [ISO]
- signaling adaptor activity [ISO]
- vascular endothelial growth factor receptor 2 binding [ISO]
- 14-3-3 protein binding [ISO]
- Ras GTPase activator activity [IBA, ISO]
- SH3 domain binding [ISO]
- Toll-like receptor 4 binding [IMP]
- death receptor binding [ISO]
- identical protein binding [ISO]
- kinase binding [ISO]
- mitogen-activated protein kinase kinase binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- phosphatidylinositol 3-kinase regulatory subunit binding [ISO]
- phosphatidylinositol-3-phosphate binding [ISO]
- phosphatidylinositol-4-phosphate binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein homodimerization activity [ISO]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [ISO]
- signaling adaptor activity [ISO]
- vascular endothelial growth factor receptor 2 binding [ISO]
Gene Ontology Cellular Component
- axon [IDA]
- cerebellar mossy fiber [IDA]
- climbing fiber [IDA]
- cytoplasm [IBA, IDA, ISO]
- endocytic vesicle [ISO]
- extracellular vesicular exosome [ISO]
- intracellular [IMP]
- intrinsic component of the cytoplasmic side of the plasma membrane [IBA]
- neuronal cell body [IDA]
- neuronal cell body membrane [IDA]
- parallel fiber [IDA]
- plasma membrane [IDA, ISO]
Mus musculus
PREY
OPHN1
C130037N19Rik, RP23-48E15.3
oligophrenin 1
GO Process (6)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Cell Syst Apr. 22, 2020; 10(4);333-350.e14 [Pubmed: 32325033]
Quantitative Score
- 0.883 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Curated By
- BioGRID