ROBO1
Gene Ontology Biological Process
- Roundabout signaling pathway [ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- axon guidance [IGI, IMP, ISO]
- axon midline choice point recognition [IGI]
- cell migration involved in sprouting angiogenesis [ISO]
- chemorepulsion involved in postnatal olfactory bulb interneuron migration [ISO]
- homophilic cell adhesion via plasma membrane adhesion molecules [ISO]
- mammary duct terminal end bud growth [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of chemokine-mediated signaling pathway [ISO]
- negative regulation of mammary gland epithelial cell proliferation [ISO]
- negative regulation of negative chemotaxis [ISO]
- olfactory bulb interneuron development [IGI]
- positive regulation of axonogenesis [ISO]
- regulation of dendrite morphogenesis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SLIT3
Gene Ontology Biological Process
- Roundabout signaling pathway [ISO]
- axon extension involved in axon guidance [ISO]
- axon guidance [IDA, ISO]
- negative chemotaxis [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of cell proliferation [IGI]
- negative regulation of chemokine-mediated signaling pathway [ISO]
- negative regulation of gene expression [IGI]
- organ morphogenesis [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain.
Connectivity webs mediate the unique biology of the mammalian brain. Yet, while cell circuit maps are increasingly available, knowledge of their underlying molecular networks remains limited. Here, we applied multi-dimensional biochemical fractionation with mass spectrometry and machine learning to survey endogenous macromolecules across the adult mouse brain. We defined a global "interactome" comprising over one thousand multi-protein complexes. These include ... [more]
Quantitative Score
- 0.941 [EPIC Score]
Throughput
- High Throughput
Additional Notes
- High confidence interactions had an EPIC Score >= 0.683
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SLIT3 ROBO1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 692216 |
Curated By
- BioGRID