SLIT3
Gene Ontology Biological Process
- Roundabout signaling pathway [ISO]
- axon extension involved in axon guidance [ISO]
- axon guidance [IDA, ISO]
- negative chemotaxis [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of cell proliferation [IGI]
- negative regulation of chemokine-mediated signaling pathway [ISO]
- negative regulation of gene expression [IGI]
- organ morphogenesis [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ROBO1
Gene Ontology Biological Process
- Roundabout signaling pathway [ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- axon guidance [IGI, IMP, ISO]
- axon midline choice point recognition [IGI]
- cell migration involved in sprouting angiogenesis [ISO]
- chemorepulsion involved in postnatal olfactory bulb interneuron migration [ISO]
- homophilic cell adhesion via plasma membrane adhesion molecules [ISO]
- mammary duct terminal end bud growth [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of chemokine-mediated signaling pathway [ISO]
- negative regulation of mammary gland epithelial cell proliferation [ISO]
- negative regulation of negative chemotaxis [ISO]
- olfactory bulb interneuron development [IGI]
- positive regulation of axonogenesis [ISO]
- regulation of dendrite morphogenesis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Repulsive axon guidance molecule Slit3 is a novel angiogenic factor.
Slits are large, secreted repulsive axon guidance molecules. Recent genetic studies revealed that the Slit3 is dispensable for neural development but required for non-neuron-related developmental processes, such as the genesis of the diaphragm and kidney. Here we report that Slit3 potently promotes angiogenesis, a process essential for proper organogenesis during embryonic development. We observed that Slit3 is expressed and secreted ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 4.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ROBO1 SLIT3 | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.941 | BioGRID | 2686394 |
Curated By
- BioGRID