BAIT

M6PR

CD-MPR, MPR 46, MPR-46, MPR46, SMPR
mannose-6-phosphate receptor (cation dependent)
Alzheimer's Disease Project
GO Process (3)
GO Function (1)
GO Component (4)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

HSPA12A

RP11-539I5.1
heat shock 70kDa protein 12A
GO Process (0)
GO Function (0)
GO Component (1)

Gene Ontology Cellular Component

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

HSPA12A targets the cytoplasmic domain and affects the trafficking of the Amyloid Precursor Protein receptor SorLA.

Madsen P, Isaksen TJ, Siupka P, Toth AE, Nyegaard M, Gustafsen C, Nielsen MS

SorLA and Sortilin are multifunctional receptors involved in endocytosis and intracellular sorting of different and unrelated ligands. SorLA has recently attracted much attention as a novel strong risk gene for Alzheimer's disease, and much effort is currently being put into understanding the underlying molecular mechanism. Trafficking of SorLA and Sortilin are mediated by interacting with AP-1, AP-2, GGA 1-3 and ... [more]

Sci Rep Dec. 24, 2018; 9(1);611 [Pubmed: 30679749]

Throughput

  • Low Throughput

Additional Notes

  • possible weak interaction

Curated By

  • BioGRID