BAIT
APOA2
Apo-AII, ApoA-II, apoAII
apolipoprotein A-II
GO Process (34)
GO Function (13)
GO Component (10)
Gene Ontology Biological Process
- cellular lipid metabolic process [TAS]
- cholesterol efflux [IDA]
- cholesterol homeostasis [IDA]
- diacylglycerol catabolic process [IDA]
- high-density lipoprotein particle assembly [IDA]
- high-density lipoprotein particle clearance [IDA]
- high-density lipoprotein particle remodeling [IDA]
- lipoprotein metabolic process [TAS]
- low-density lipoprotein particle remodeling [IDA]
- negative regulation of cholesterol import [IDA]
- negative regulation of cholesterol transport [IMP]
- negative regulation of cholesterol transporter activity [IDA]
- negative regulation of cytokine secretion involved in immune response [IDA]
- negative regulation of lipase activity [IDA]
- negative regulation of lipid catabolic process [IDA]
- negative regulation of very-low-density lipoprotein particle remodeling [IDA]
- peptidyl-methionine modification [IDA]
- phosphatidylcholine biosynthetic process [IDA]
- phospholipid catabolic process [IDA]
- phospholipid efflux [IDA]
- phototransduction, visible light [TAS]
- positive regulation of catalytic activity [IDA]
- positive regulation of cholesterol esterification [IDA]
- positive regulation of interleukin-8 biosynthetic process [IDA]
- positive regulation of lipid catabolic process [IDA]
- protein folding [IDA]
- protein oxidation [IDA]
- regulation of protein stability [IDA]
- response to glucose [IDA]
- retinoid metabolic process [TAS]
- reverse cholesterol transport [IDA]
- small molecule metabolic process [TAS]
- triglyceride metabolic process [TAS]
- triglyceride-rich lipoprotein particle remodeling [IDA]
Gene Ontology Molecular Function- apolipoprotein receptor binding [IPI]
- cholesterol binding [IDA]
- cholesterol transporter activity [IDA]
- high-density lipoprotein particle receptor binding [IPI]
- lipase inhibitor activity [IDA]
- lipid binding [IDA]
- lipid transporter activity [IDA]
- phosphatidylcholine binding [IDA]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IDA]
- phospholipid binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IDA]
- apolipoprotein receptor binding [IPI]
- cholesterol binding [IDA]
- cholesterol transporter activity [IDA]
- high-density lipoprotein particle receptor binding [IPI]
- lipase inhibitor activity [IDA]
- lipid binding [IDA]
- lipid transporter activity [IDA]
- phosphatidylcholine binding [IDA]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IDA]
- phospholipid binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IDA]
Gene Ontology Cellular Component
- blood microparticle [IDA]
- chylomicron [IDA]
- cytosol [TAS]
- early endosome [TAS]
- endoplasmic reticulum lumen [TAS]
- extracellular region [NAS, TAS]
- extracellular vesicular exosome [IDA]
- high-density lipoprotein particle [IDA]
- spherical high-density lipoprotein particle [IDA]
- very-low-density lipoprotein particle [IDA]
Homo sapiens
PREY
CREB3
LUMAN, LZIP, sLZIP
cAMP responsive element binding protein 3
GO Process (20)
GO Function (12)
GO Component (12)
Gene Ontology Biological Process
- cytoplasmic sequestering of transcription factor [IDA]
- establishment of viral latency [IDA]
- induction of positive chemotaxis [IDA, IMP]
- negative regulation of cell cycle [NAS]
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [IDA]
- negative regulation of ligand-dependent nuclear receptor transcription coactivator activity [IDA]
- positive regulation of calcium ion transport [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of deacetylase activity [IDA]
- positive regulation of defense response to virus by host [IDA]
- positive regulation of monocyte chemotaxis [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of cell growth [IDA]
- regulation of cell proliferation [IMP]
- release from viral latency [IDA, TAS]
- response to endoplasmic reticulum stress [IDA]
- transcription from RNA polymerase II promoter [IDA]
- transcription, DNA-templated [IDA]
Gene Ontology Molecular Function- CCR1 chemokine receptor binding [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- cAMP response element binding protein binding [IDA]
- chromatin binding [IDA]
- protein binding [IPI]
- protein dimerization activity [TAS]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- CCR1 chemokine receptor binding [IDA]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IMP]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- cAMP response element binding protein binding [IDA]
- chromatin binding [IDA]
- protein binding [IPI]
- protein dimerization activity [TAS]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
Gene Ontology Cellular Component
- Golgi apparatus [IMP]
- Golgi membrane [IDA]
- cytoplasm [IDA, IMP]
- cytosol [IMP]
- endoplasmic reticulum [IDA, IMP]
- endoplasmic reticulum membrane [IDA]
- integral component of endoplasmic reticulum membrane [IDA]
- integral component of membrane [IDA]
- membrane [IDA]
- neuronal cell body [IDA]
- nuclear body [IDA]
- nucleus [IC, IDA]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.
Identifying disease-associated missense mutations remains a challenge, especially in large-scale sequencing studies. Here we establish an experimentally and computationally integrated approach to investigate the functional impact of missense mutations in the context of the human interactome network and test our approach by analyzing ~2,000 de novo missense mutations found in autism subjects and their unaffected siblings. Interaction-disrupting de novo missense ... [more]
Nat. Genet. Dec. 01, 2017; 50(7);1032-1040 [Pubmed: 29892012]
Throughput
- High Throughput
Additional Notes
- this interaction found to remain intact in at least one case as part of an assessment of the effect on protein-protein interactions of autism-spectrum disorder mutations in the bait proteins
- this interaction was found to remain intact in the case of at least one bait protein mutation as part of an assessment of the effect on protein-protein interactions of autism-spectrum disorder mutations in the bait proteins
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CREB3 APOA2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID