BAIT
IGF2BP1
CRD-BP, CRDBP, IMP-1, IMP1, VICKZ1, ZBP1
insulin-like growth factor 2 mRNA binding protein 1
GO Process (5)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
EHMT2
BAT8, C6orf30, G9A, GAT8, KMT1C, NG36, DAAP-66K18.3
euchromatic histone-lysine N-methyltransferase 2
GO Process (6)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors.
Modulators of mRNA stability are not well understood in melanoma, an aggressive tumor with complex changes in the transcriptome. Here we report the ability of p62/SQSTM1 to extend mRNA half-life of a spectrum of pro-metastatic factors. These include FERMT2 and other transcripts with no previous links to melanoma. Transcriptomic, proteomic, and interactomic analyses, combined with validation in clinical biopsies and ... [more]
Cancer Cell Dec. 14, 2018; 35(1);46-63.e10 [Pubmed: 30581152]
Throughput
- Low Throughput
Additional Notes
- interaction of the protein corresponding to the bait gene IGF2BP1 with mRNA corresponding to the indicated hit genes, assayed using RIP (RNA immunoprecipitation) followed by RT-qPCR (real time quantitative polymerase chain reaction)
Curated By
- BioGRID