BAIT

ARPC3

ARC21, p21-Arc

actin related protein 2/3 complex, subunit 3, 21kDa

GO Process (4)

GO Function (3)

GO Component (6)

Gene Ontology Biological Process

Arp2/3 complex-mediated actin nucleation [IDA]

Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]

cellular component movement [TAS]

innate immune response [TAS]

Gene Ontology Molecular Function

actin filament binding [IDA]
protein binding [IPI]
structural constituent of cytoskeleton [IDA]

Gene Ontology Cellular Component

Arp2/3 protein complex [IDA]

actin cytoskeleton [TAS]

extracellular vesicular exosome [IDA]

focal adhesion [IDA]

CRISPR Database OMIM HGNC Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

PRMT1

ANM1, HCP1, HRMT1L2, IR1B4

protein arginine methyltransferase 1

Cell Cycle - Mitotic Spindle Assembly Project

Human Papilloma Virus (HPV) Project

GO Process (9)

GO Function (8)

GO Component (3)

Gene Ontology Biological Process

cell surface receptor signaling pathway [TAS]

histone H4-R3 methylation [IDA]

histone methylation [IDA]

negative regulation of megakaryocyte differentiation [IDA]

neuron projection development [IMP]

peptidyl-arginine methylation [IDA]

peptidyl-arginine methylation, to asymmetrical-dimethyl arginine [IBA]

protein methylation [TAS]

regulation of transcription, DNA-templated [IBA]

Gene Ontology Molecular Function

N-methyltransferase activity [IDA, IMP]
histone methyltransferase activity [IDA]
histone methyltransferase activity (H4-R3 specific) [IDA]
identical protein binding [IPI]
methyltransferase activity [TAS]
poly(A) RNA binding [IDA]
protein binding [IPI]
protein-arginine omega-N asymmetric methyltransferase activity [IBA]

Gene Ontology Cellular Component

cytoplasm [TAS]

CRISPR Database HGNC Alliance of Genome Resources VEGA OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

A human protein-protein interaction network: a resource for annotating the proteome.

Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksoez E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE

Protein-protein interaction maps provide a valuable framework for a better understanding of the functional organization of the proteome. To detect interacting pairs of human proteins systematically, a protein matrix of 4456 baits and 5632 preys was screened by automated yeast two-hybrid (Y2H) interaction mating. We identified 3186 mostly novel interactions among 1705 proteins, resulting in a large, highly connected network. ... [more]

Cell Sep. 23, 2005; 122(6);957-68 [Pubmed: 16169070]

Quantitative Score

1.0 [Confidence Score]

Throughput

High Throughput

Curated By

BioGRID