BAIT
EDN1
ARCND3, ET1, HDLCQ7, PPET1, QME
endothelin 1
GO Process (37)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- artery smooth muscle contraction [IDA, TAS]
- calcium-mediated signaling [IDA]
- cell surface receptor signaling pathway [IDA]
- cell-cell signaling [IDA]
- inositol phosphate-mediated signaling [IDA]
- leukocyte activation [TAS]
- negative regulation of blood coagulation [TAS]
- negative regulation of cellular protein metabolic process [IDA]
- negative regulation of nitric-oxide synthase biosynthetic process [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- neutrophil chemotaxis [IDA]
- nitric oxide transport [IDA]
- peptide hormone secretion [IDA]
- phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of JUN kinase activity [IDA]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of cardiac muscle hypertrophy [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of cell size [IDA]
- positive regulation of chemokine-mediated signaling pathway [IC]
- positive regulation of cytosolic calcium ion concentration [IDA]
- positive regulation of endothelial cell migration [TAS]
- positive regulation of heart rate [IDA]
- positive regulation of hormone secretion [IDA]
- positive regulation of mitosis [IDA]
- positive regulation of nitric oxide biosynthetic process [TAS]
- positive regulation of prostaglandin-endoperoxide synthase activity [IMP]
- positive regulation of receptor biosynthetic process [IDA]
- positive regulation of sarcomere organization [IMP]
- positive regulation of smooth muscle cell proliferation [IDA]
- prostaglandin biosynthetic process [IDA]
- protein kinase C deactivation [IDA]
- regulation of systemic arterial blood pressure by endothelin [IDA]
- vasoconstriction [IDA]
- vein smooth muscle contraction [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
BAG6
BAG-6, BAT3, D6S52E, G3, DADB-70P7.10-021
BCL2-associated athanogene 6
GO Process (14)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
- brain development [ISS]
- embryo development [ISS]
- internal peptidyl-lysine acetylation [IDA]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IMP]
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISS]
- kidney development [ISS]
- lung development [ISS]
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process [ISS]
- negative regulation of proteolysis [ISS]
- protein stabilization [ISS]
- spermatogenesis [ISS]
- synaptonemal complex assembly [ISS]
- tail-anchored membrane protein insertion into ER membrane [IDA]
- ubiquitin-dependent protein catabolic process [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A human protein-protein interaction network: a resource for annotating the proteome.
Protein-protein interaction maps provide a valuable framework for a better understanding of the functional organization of the proteome. To detect interacting pairs of human proteins systematically, a protein matrix of 4456 baits and 5632 preys was screened by automated yeast two-hybrid (Y2H) interaction mating. We identified 3186 mostly novel interactions among 1705 proteins, resulting in a large, highly connected network. ... [more]
Cell Sep. 23, 2005; 122(6);957-68 [Pubmed: 16169070]
Quantitative Score
- 1.0 [Confidence Score]
Throughput
- High Throughput
Curated By
- BioGRID