BAIT
CD74
DHLAG, HLADG, II, Ia-GAMMA
CD74 molecule, major histocompatibility complex, class II invariant chain
GO Process (22)
GO Function (10)
GO Component (18)
Gene Ontology Biological Process
- T cell selection [NAS]
- antigen processing and presentation of endogenous antigen [NAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- cell proliferation [IDA]
- immunoglobulin mediated immune response [ISS]
- intracellular protein transport [ISS]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [IDA]
- negative regulation of apoptotic process [IDA]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IMP]
- negative regulation of peptide secretion [IDA]
- positive regulation of B cell proliferation [IMP]
- positive regulation of ERK1 and ERK2 cascade [IDA, IMP]
- positive regulation of chemokine (C-X-C motif) ligand 2 production [ISS]
- positive regulation of cytokine-mediated signaling pathway [IMP]
- positive regulation of fibroblast proliferation [IMP]
- positive regulation of macrophage cytokine production [ISS]
- positive regulation of neutrophil chemotaxis [ISS]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- prostaglandin biosynthetic process [IDA]
- protein complex assembly [ISS]
- regulation of macrophage activation [NAS]
- signal transduction [IDA]
Gene Ontology Molecular Function- MHC class II protein binding [ISS, NAS]
- MHC class II protein binding, via antigen binding groove [IDA]
- MHC class II protein complex binding [IDA]
- beta-amyloid binding [IPI]
- cytokine binding [IPI]
- cytokine receptor activity [IDA]
- identical protein binding [TAS]
- macrophage migration inhibitory factor binding [IPI]
- protein binding [IPI]
- protein binding involved in protein folding [IDA]
- MHC class II protein binding [ISS, NAS]
- MHC class II protein binding, via antigen binding groove [IDA]
- MHC class II protein complex binding [IDA]
- beta-amyloid binding [IPI]
- cytokine binding [IPI]
- cytokine receptor activity [IDA]
- identical protein binding [TAS]
- macrophage migration inhibitory factor binding [IPI]
- protein binding [IPI]
- protein binding involved in protein folding [IDA]
Gene Ontology Cellular Component
- ER to Golgi transport vesicle membrane [TAS]
- Golgi membrane [TAS]
- MHC class II protein complex [ISS]
- cell surface [IDA]
- clathrin-coated endocytic vesicle membrane [TAS]
- endocytic vesicle membrane [TAS]
- extracellular vesicular exosome [IDA]
- integral component of lumenal side of endoplasmic reticulum membrane [TAS]
- integral component of membrane [IDA]
- intracellular [TAS]
- lysosomal lumen [TAS]
- lysosomal membrane [TAS]
- macrophage migration inhibitory factor receptor complex [IDA]
- membrane [IDA]
- plasma membrane [TAS]
- trans-Golgi network membrane [TAS]
- transport vesicle membrane [TAS]
- vacuole [IDA]
Homo sapiens
PREY
PLP1
GPM6C, HLD1, MMPL, PLP, PLP/DM20, PMD, SPG2, GHc-698D2.1
proteolipid protein 1
GO Process (3)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A reference map of the human binary protein interactome.
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships1,2. Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration ... [more]
Nature Apr. 01, 2020; 580(7803);402-408 [Pubmed: 32296183]
Throughput
- High Throughput
Additional Notes
- This human reference interactome (HuRI) was generated by performing nine two-hybrid screens with the high confidence interactions determined by pairwise verification by quadruplicate retesting and sequence confirmation. This HI-III-20 dataset contains over 52,000 PPIs involving more than 8,000 proteins.
Curated By
- BioGRID