BAIT
MAPRE3
EB3, EBF3, EBF3-S, RP3
microtubule-associated protein, RP/EB family, member 3
GO Process (2)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ANKRD1
ALRP, C-193, CARP, CVARP, MCARP, bA320F15.2
ankyrin repeat domain 1 (cardiac muscle)
GO Process (15)
GO Function (9)
GO Component (7)
Gene Ontology Biological Process
- cardiac muscle tissue morphogenesis [IMP]
- cellular lipid metabolic process [TAS]
- cellular response to interleukin-1 [IDA]
- cellular response to lipopolysaccharide [IDA]
- cellular response to mechanical stimulus [IDA]
- cellular response to transforming growth factor beta stimulus [IDA]
- cellular response to tumor necrosis factor [IDA]
- negative regulation of DNA biosynthetic process [IMP]
- positive regulation of DNA damage response, signal transduction by p53 class mediator [IDA]
- positive regulation of apoptotic process [IMP]
- positive regulation of protein secretion [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- response to muscle stretch [IMP]
- sarcomere organization [NAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A reference map of the human binary protein interactome.
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships1,2. Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration ... [more]
Nature Apr. 01, 2020; 580(7803);402-408 [Pubmed: 32296183]
Throughput
- High Throughput
Additional Notes
- This human reference interactome (HuRI) was generated by performing nine two-hybrid screens with the high confidence interactions determined by pairwise verification by quadruplicate retesting and sequence confirmation. This HI-III-20 dataset contains over 52,000 PPIs involving more than 8,000 proteins.
Curated By
- BioGRID