BAIT
TRIM3
BERP, HAC1, RNF22, RNF97
tripartite motif containing 3
GO Process (1)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
TRIM21
RNF81, RO52, Ro/SSA, SSA, SSA1
tripartite motif containing 21
GO Process (15)
GO Function (3)
GO Component (6)
Gene Ontology Biological Process
- innate immune response [IDA, TAS]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of protein deubiquitination [IMP]
- negative regulation of viral release from host cell [IDA]
- negative regulation of viral transcription [IDA]
- positive regulation of cell cycle [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of type I interferon production [TAS]
- protein autoubiquitination [IDA]
- protein destabilization [IMP]
- protein monoubiquitination [IDA]
- protein polyubiquitination [IDA]
- protein trimerization [IDA]
- protein ubiquitination [IDA]
- regulation of type I interferon production [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A reference map of the human binary protein interactome.
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships1,2. Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration ... [more]
Nature Apr. 01, 2020; 580(7803);402-408 [Pubmed: 32296183]
Throughput
- High Throughput
Additional Notes
- This human reference interactome (HuRI) was generated by performing nine two-hybrid screens with the high confidence interactions determined by pairwise verification by quadruplicate retesting and sequence confirmation. This HI-III-20 dataset contains over 52,000 PPIs involving more than 8,000 proteins.
Curated By
- BioGRID