BAIT
EIF4G1
EIF-4G1, EIF4F, EIF4G, EIF4GI, P220, PARK18
eukaryotic translation initiation factor 4 gamma, 1
GO Process (12)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- cellular protein metabolic process [TAS]
- cytokine-mediated signaling pathway [TAS]
- gene expression [TAS]
- insulin receptor signaling pathway [TAS]
- mRNA metabolic process [TAS]
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [TAS]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [TAS]
- nuclear-transcribed mRNA poly(A) tail shortening [TAS]
- regulation of translational initiation [IMP, NAS]
- translation [TAS]
- translational initiation [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
CIB1
CIB, CIBP, KIP1, PRKDCIP, SIP2-28
calcium and integrin binding 1 (calmyrin)
GO Process (38)
GO Function (4)
GO Component (17)
Gene Ontology Biological Process
- apoptotic process [IMP]
- cellular response to DNA damage stimulus [IDA]
- cellular response to growth factor stimulus [ISS]
- cellular response to nerve growth factor stimulus [IDA]
- cellular response to tumor necrosis factor [IMP]
- cytoplasmic microtubule organization [IMP]
- double-strand break repair [TAS]
- endomitotic cell cycle [IDA]
- extrinsic apoptotic signaling pathway [TAS]
- negative regulation of apoptotic process [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of megakaryocyte differentiation [ISS]
- negative regulation of microtubule depolymerization [IDA]
- negative regulation of neuron projection development [IDA]
- negative regulation of protein kinase B signaling [ISS]
- negative regulation of protein phosphorylation [ISS]
- platelet formation [ISS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of calcineurin-NFAT signaling cascade [IDA]
- positive regulation of cell adhesion mediated by integrin [IDA]
- positive regulation of cell growth [ISS]
- positive regulation of cell migration [ISS]
- positive regulation of cell migration involved in sprouting angiogenesis [ISS]
- positive regulation of cell proliferation [ISS]
- positive regulation of cell-matrix adhesion [ISS]
- positive regulation of establishment of protein localization to plasma membrane [IGI]
- positive regulation of male germ cell proliferation [ISS]
- positive regulation of metalloenzyme activity [ISS]
- positive regulation of protein phosphorylation [ISS]
- positive regulation of protein serine/threonine kinase activity [ISS]
- positive regulation of protein targeting to membrane [IMP]
- positive regulation of substrate adhesion-dependent cell spreading [IDA]
- regulation of cell division [IMP]
- regulation of cell proliferation [IMP]
- response to ischemia [ISS]
- spermatid development [ISS]
- thrombopoietin-mediated signaling pathway [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell periphery [IDA]
- centrosome [IDA]
- cytoplasm [IDA, IMP]
- endoplasmic reticulum [IMP]
- extracellular vesicular exosome [IDA]
- filopodium tip [IDA]
- growth cone [IDA]
- lamellipodium [IDA]
- membrane [IDA]
- neuron projection [IDA]
- neuronal cell body [IDA]
- nucleoplasm [IDA, IMP]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA]
- sarcolemma [IDA]
- vesicle [IDA]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A reference map of the human binary protein interactome.
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships1,2. Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration ... [more]
Nature Apr. 01, 2020; 580(7803);402-408 [Pubmed: 32296183]
Throughput
- High Throughput
Additional Notes
- This human reference interactome (HuRI) was generated by performing nine two-hybrid screens with the high confidence interactions determined by pairwise verification by quadruplicate retesting and sequence confirmation. This HI-III-20 dataset contains over 52,000 PPIs involving more than 8,000 proteins.
Curated By
- BioGRID