BAIT
MGST3
GST-III, RP11-466F5.1
microsomal glutathione S-transferase 3
GO Process (6)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PLN
CMD1P, CMH18, PLB, RP3-509L4.2
phospholamban
GO Process (19)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- blood circulation [NAS]
- cytosolic calcium ion homeostasis [IC]
- negative regulation of ATPase activity [IDA, ISS]
- negative regulation of calcium ion binding [IDA, ISS]
- negative regulation of calcium ion import [ISS]
- negative regulation of calcium ion import into sarcoplasmic reticulum [ISS]
- negative regulation of calcium ion transmembrane transporter activity [IDA, ISS]
- negative regulation of calcium ion transport [IDA]
- negative regulation of calcium-transporting ATPase activity [IDA]
- negative regulation of catalytic activity [ISS]
- negative regulation of heart rate [IMP]
- regulation of calcium ion transport [IDA, ISS]
- regulation of calcium-transporting ATPase activity [IDA]
- regulation of cardiac muscle cell contraction [IC]
- regulation of cardiac muscle cell membrane potential [IC]
- regulation of heart contraction [IMP]
- regulation of relaxation of cardiac muscle [IC]
- regulation of the force of heart contraction [IC]
- relaxation of cardiac muscle [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A reference map of the human binary protein interactome.
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships1,2. Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration ... [more]
Nature Apr. 01, 2020; 580(7803);402-408 [Pubmed: 32296183]
Throughput
- High Throughput
Additional Notes
- This human reference interactome (HuRI) was generated by performing nine two-hybrid screens with the high confidence interactions determined by pairwise verification by quadruplicate retesting and sequence confirmation. This HI-III-20 dataset contains over 52,000 PPIs involving more than 8,000 proteins.
Curated By
- BioGRID