BAIT
GHRL
MTLRP, UNQ524/PRO1066
ghrelin/obestatin prepropeptide
GO Process (36)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISS, TAS]
- actin polymerization or depolymerization [IDA]
- activation of MAPK activity [IMP]
- adult feeding behavior [ISS]
- cartilage development [NAS]
- cellular protein metabolic process [TAS]
- cortisol secretion [NAS]
- decidualization [IDA]
- dendrite development [IDA]
- gastric acid secretion [IBA]
- glucose metabolic process [NAS]
- growth hormone secretion [TAS]
- hormone-mediated signaling pathway [TAS]
- negative regulation of angiogenesis [NAS]
- negative regulation of apoptotic process [IDA]
- negative regulation of circadian sleep/wake cycle, REM sleep [IDA]
- negative regulation of endothelial cell proliferation [IDA]
- negative regulation of inflammatory response [IDA]
- negative regulation of interleukin-1 beta production [IDA]
- negative regulation of interleukin-6 biosynthetic process [IDA]
- negative regulation of tumor necrosis factor biosynthetic process [IDA]
- positive regulation of appetite [ISS]
- positive regulation of circadian sleep/wake cycle, non-REM sleep [IDA]
- positive regulation of corticotropin secretion [IDA]
- positive regulation of cortisol secretion [IDA]
- positive regulation of cytosolic calcium ion concentration [ISS]
- positive regulation of growth hormone receptor signaling pathway [IC]
- positive regulation of growth hormone secretion [IDA]
- positive regulation of insulin secretion [ISS]
- positive regulation of multicellular organism growth [IC]
- positive regulation of protein tyrosine kinase activity [IMP]
- positive regulation of synapse assembly [IDA]
- regulation of cell proliferation [IDA]
- regulation of response to food [IBA]
- response to estrogen [IDA]
- response to hormone [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
UBQLN2
ALS15, CHAP1, DSK2, N4BP4, PLIC2, HRIHFB2157
ubiquilin 2
GO Process (0)
GO Function (1)
GO Component (2)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A reference map of the human binary protein interactome.
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships1,2. Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration ... [more]
Nature Apr. 01, 2020; 580(7803);402-408 [Pubmed: 32296183]
Throughput
- High Throughput
Additional Notes
- This human reference interactome (HuRI) was generated by performing nine two-hybrid screens with the high confidence interactions determined by pairwise verification by quadruplicate retesting and sequence confirmation. This HI-III-20 dataset contains over 52,000 PPIs involving more than 8,000 proteins.
Curated By
- BioGRID