BAIT
FOXH1
FAST-1, FAST1
forkhead box H1
GO Process (7)
GO Function (13)
GO Component (5)
Gene Ontology Biological Process
- negative regulation of androgen receptor activity [IDA]
- negative regulation of androgen receptor signaling pathway [IDA]
- negative regulation of intracellular estrogen receptor signaling pathway [IDA]
- nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [NAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- transforming growth factor beta receptor signaling pathway [ISS, TAS]
Gene Ontology Molecular Function- DNA binding [IDA]
- R-SMAD binding [IMP, IPI]
- SMAD binding [IPI]
- androgen receptor binding [IPI]
- bHLH transcription factor binding [IPI]
- co-SMAD binding [IMP]
- enhancer binding [IC]
- protein binding [IPI]
- protein domain specific binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IBA]
- sequence-specific DNA binding transcription factor activity [IDA, NAS]
- transcription regulatory region DNA binding [ISS]
- DNA binding [IDA]
- R-SMAD binding [IMP, IPI]
- SMAD binding [IPI]
- androgen receptor binding [IPI]
- bHLH transcription factor binding [IPI]
- co-SMAD binding [IMP]
- enhancer binding [IC]
- protein binding [IPI]
- protein domain specific binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IBA]
- sequence-specific DNA binding transcription factor activity [IDA, NAS]
- transcription regulatory region DNA binding [ISS]
Gene Ontology Cellular Component
Homo sapiens
PREY
TSC1
LAM, TSC
tuberous sclerosis 1
GO Process (17)
GO Function (4)
GO Component (9)
Gene Ontology Biological Process
- activation of Rho GTPase activity [IDA]
- cell cycle arrest [TAS]
- cell-matrix adhesion [IMP]
- insulin receptor signaling pathway [TAS]
- negative regulation of TOR signaling [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of insulin receptor signaling pathway [IBA]
- negative regulation of translation [IMP]
- positive regulation of focal adhesion assembly [IDA]
- protein stabilization [IDA]
- rRNA export from nucleus [IMP]
- regulation of cell cycle [IBA]
- regulation of cell-matrix adhesion [IMP]
- regulation of phosphoprotein phosphatase activity [IMP]
- regulation of stress fiber assembly [IDA]
- regulation of translation [IDA]
- response to insulin [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A reference map of the human binary protein interactome.
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships1,2. Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration ... [more]
Nature Apr. 01, 2020; 580(7803);402-408 [Pubmed: 32296183]
Throughput
- High Throughput
Additional Notes
- This human reference interactome (HuRI) was generated by performing nine two-hybrid screens with the high confidence interactions determined by pairwise verification by quadruplicate retesting and sequence confirmation. This HI-III-20 dataset contains over 52,000 PPIs involving more than 8,000 proteins.
Curated By
- BioGRID