BAIT
GOLGA2
GM130, RP11-395P17.5
golgin A2
GO Process (2)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
FOXC2
FKHL14, LD, MFH-1, MFH1
forkhead box C2
GO Process (13)
GO Function (5)
GO Component (1)
Gene Ontology Biological Process
- heart development [IMP]
- insulin receptor signaling pathway [IDA]
- lymphangiogenesis [IMP]
- mesoderm development [NAS]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of cell adhesion mediated by integrin [ISS]
- positive regulation of cell migration involved in sprouting angiogenesis [ISS]
- positive regulation of endothelial cell migration [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of vascular wound healing [ISS]
- regulation of transcription from RNA polymerase II promoter [IBA]
- response to hormone [IDA]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- chromatin DNA binding [IDA]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region DNA binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- chromatin DNA binding [IDA]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region DNA binding [ISS]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A reference map of the human binary protein interactome.
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships1,2. Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration ... [more]
Nature Apr. 01, 2020; 580(7803);402-408 [Pubmed: 32296183]
Throughput
- High Throughput
Additional Notes
- This human reference interactome (HuRI) was generated by performing nine two-hybrid screens with the high confidence interactions determined by pairwise verification by quadruplicate retesting and sequence confirmation. This HI-III-20 dataset contains over 52,000 PPIs involving more than 8,000 proteins.
Curated By
- BioGRID