BAIT
PRAF2
JM4
PRA1 domain family, member 2
GO Process (1)
GO Function (0)
GO Component (0)
Gene Ontology Biological Process
Homo sapiens
PREY
GJA5
ATFB11, CX40
gap junction protein, alpha 5, 40kDa
GO Process (15)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- AV node cell to bundle of His cell communication by electrical coupling [IMP]
- angiogenesis [IEP]
- artery morphogenesis [ISS]
- atrial cardiac muscle cell action potential [IMP]
- atrial septum development [IMP]
- bundle of His cell to Purkinje myocyte communication [IMP]
- cell communication by electrical coupling involved in cardiac conduction [IDA]
- gap junction assembly [IDA, IMP]
- mitral valve development [IMP]
- outflow tract morphogenesis [IMP]
- pulmonary valve formation [IMP]
- regulation of atrial cardiac muscle cell membrane depolarization [IMP]
- regulation of cardiac muscle contraction [IMP]
- transmembrane transport [IDA]
- ventricular septum development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A reference map of the human binary protein interactome.
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships1,2. Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integration ... [more]
Nature Apr. 01, 2020; 580(7803);402-408 [Pubmed: 32296183]
Throughput
- High Throughput
Additional Notes
- This human reference interactome (HuRI) was generated by performing nine two-hybrid screens with the high confidence interactions determined by pairwise verification by quadruplicate retesting and sequence confirmation. This HI-III-20 dataset contains over 52,000 PPIs involving more than 8,000 proteins.
Curated By
- BioGRID