Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

MST4, a new Ste20-related kinase that mediates cell growth and transformation via modulating ERK pathway.

Lin JL, Chen HC, Fang HI, Robinson D, Kung HJ, Shih HM

In this study, we report the cloning and characterization of a novel human Ste20-related kinase that we designated MST4. The 416 amino acid full-length MST4 contains an amino-terminal kinase domain, which is highly homologous to MST3 and SOK, and a unique carboxy-terminal domain. Northern blot analysis indicated that MST4 is highly expressed in placenta, thymus, and peripheral blood leukocytes. Wild-type ... [more]

Oncogene Oct. 04, 2001; 20(45);6559-69 [Pubmed: 11641781]

Throughput

  • Low Throughput

Curated By

  • BioGRID