BAIT
VEGFA
MVCD1, VEGF, VPF, RP1-261G23.1
vascular endothelial growth factor A
GO Process (97)
GO Function (16)
GO Component (7)
Gene Ontology Biological Process
- VEGF-activated neuropilin signaling pathway [ISS]
- activation of protein kinase activity [IDA]
- angiogenesis [IDA]
- artery morphogenesis [ISS]
- basophil chemotaxis [IDA]
- blood coagulation [TAS]
- branching morphogenesis of an epithelial tube [ISS]
- camera-type eye morphogenesis [ISS]
- cardiac muscle fiber development [ISS]
- cardiac vascular smooth muscle cell development [ISS]
- cell maturation [ISS]
- cell migration involved in sprouting angiogenesis [IDA]
- cellular response to hypoxia [IDA, TAS]
- cellular response to vascular endothelial growth factor stimulus [IDA]
- commissural neuron axon guidance [ISS]
- coronary artery morphogenesis [ISS]
- coronary vein morphogenesis [ISS]
- dopaminergic neuron differentiation [ISS]
- endothelial cell chemotaxis [IDA]
- epithelial cell differentiation [ISS]
- eye photoreceptor cell development [ISS]
- growth [ISS]
- heart morphogenesis [ISS]
- in utero embryonic development [ISS]
- induction of positive chemotaxis [IDA, NAS]
- kidney development [ISS]
- lactation [ISS]
- lung development [ISS]
- lymph vessel morphogenesis [ISS]
- macrophage differentiation [IDA]
- mammary gland alveolus development [ISS]
- mesoderm development [ISS]
- monocyte differentiation [IDA]
- negative regulation of apoptotic process [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- nervous system development [TAS]
- outflow tract morphogenesis [ISS]
- ovarian follicle development [ISS]
- patterning of blood vessels [ISS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive chemotaxis [IDA]
- positive regulation of CREB transcription factor activity [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of angiogenesis [IDA, IMP]
- positive regulation of axon extension involved in axon guidance [ISS]
- positive regulation of blood vessel endothelial cell migration [IDA]
- positive regulation of branching involved in ureteric bud morphogenesis [ISS]
- positive regulation of cell adhesion [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of cell migration involved in sprouting angiogenesis [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [IDA]
- positive regulation of cellular component movement [IDA]
- positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [IDA]
- positive regulation of endothelial cell migration [IDA]
- positive regulation of endothelial cell proliferation [IDA, ISS]
- positive regulation of epithelial cell proliferation [ISS]
- positive regulation of focal adhesion assembly [IDA]
- positive regulation of gene expression [IDA]
- positive regulation of histone deacetylase activity [IDA]
- positive regulation of leukocyte migration [TAS]
- positive regulation of mast cell chemotaxis [IDA]
- positive regulation of mesenchymal cell proliferation [ISS]
- positive regulation of neuroblast proliferation [ISS]
- positive regulation of p38MAPK cascade [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of peptidyl-tyrosine autophosphorylation [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of positive chemotaxis [IDA]
- positive regulation of protein autophosphorylation [IDA]
- positive regulation of protein complex assembly [IDA]
- positive regulation of protein kinase C signaling [IDA]
- positive regulation of protein kinase D signaling [IDA]
- positive regulation of protein localization to early endosome [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of receptor internalization [IDA]
- positive regulation of retinal ganglion cell axon guidance [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [IMP]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IDA]
- positive regulation of vascular permeability [IDA]
- post-embryonic camera-type eye development [ISS]
- primitive erythrocyte differentiation [ISS]
- regulation of cGMP metabolic process [IDA]
- regulation of cell shape [IDA]
- regulation of retinal ganglion cell axon guidance [ISS]
- regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- response to hypoxia [IDA]
- surfactant homeostasis [ISS]
- tube formation [IDA]
- vascular endothelial growth factor receptor signaling pathway [IDA, TAS]
- vascular endothelial growth factor signaling pathway [IDA]
- vasculogenesis [TAS]
Gene Ontology Molecular Function- chemoattractant activity [IDA]
- cytokine activity [IDA, ISS]
- extracellular matrix binding [IC]
- fibronectin binding [IDA]
- growth factor activity [IDA, ISS]
- heparin binding [IDA, IMP]
- identical protein binding [IPI]
- neuropilin binding [IPI]
- platelet-derived growth factor receptor binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [ISS]
- receptor agonist activity [IPI]
- vascular endothelial growth factor receptor 1 binding [IPI]
- vascular endothelial growth factor receptor 2 binding [IPI]
- vascular endothelial growth factor receptor binding [IPI]
- chemoattractant activity [IDA]
- cytokine activity [IDA, ISS]
- extracellular matrix binding [IC]
- fibronectin binding [IDA]
- growth factor activity [IDA, ISS]
- heparin binding [IDA, IMP]
- identical protein binding [IPI]
- neuropilin binding [IPI]
- platelet-derived growth factor receptor binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [ISS]
- receptor agonist activity [IPI]
- vascular endothelial growth factor receptor 1 binding [IPI]
- vascular endothelial growth factor receptor 2 binding [IPI]
- vascular endothelial growth factor receptor binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
VEGFA
MVCD1, VEGF, VPF, RP1-261G23.1
vascular endothelial growth factor A
GO Process (97)
GO Function (16)
GO Component (7)
Gene Ontology Biological Process
- VEGF-activated neuropilin signaling pathway [ISS]
- activation of protein kinase activity [IDA]
- angiogenesis [IDA]
- artery morphogenesis [ISS]
- basophil chemotaxis [IDA]
- blood coagulation [TAS]
- branching morphogenesis of an epithelial tube [ISS]
- camera-type eye morphogenesis [ISS]
- cardiac muscle fiber development [ISS]
- cardiac vascular smooth muscle cell development [ISS]
- cell maturation [ISS]
- cell migration involved in sprouting angiogenesis [IDA]
- cellular response to hypoxia [IDA, TAS]
- cellular response to vascular endothelial growth factor stimulus [IDA]
- commissural neuron axon guidance [ISS]
- coronary artery morphogenesis [ISS]
- coronary vein morphogenesis [ISS]
- dopaminergic neuron differentiation [ISS]
- endothelial cell chemotaxis [IDA]
- epithelial cell differentiation [ISS]
- eye photoreceptor cell development [ISS]
- growth [ISS]
- heart morphogenesis [ISS]
- in utero embryonic development [ISS]
- induction of positive chemotaxis [IDA, NAS]
- kidney development [ISS]
- lactation [ISS]
- lung development [ISS]
- lymph vessel morphogenesis [ISS]
- macrophage differentiation [IDA]
- mammary gland alveolus development [ISS]
- mesoderm development [ISS]
- monocyte differentiation [IDA]
- negative regulation of apoptotic process [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- nervous system development [TAS]
- outflow tract morphogenesis [ISS]
- ovarian follicle development [ISS]
- patterning of blood vessels [ISS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive chemotaxis [IDA]
- positive regulation of CREB transcription factor activity [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of angiogenesis [IDA, IMP]
- positive regulation of axon extension involved in axon guidance [ISS]
- positive regulation of blood vessel endothelial cell migration [IDA]
- positive regulation of branching involved in ureteric bud morphogenesis [ISS]
- positive regulation of cell adhesion [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of cell migration involved in sprouting angiogenesis [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [IDA]
- positive regulation of cellular component movement [IDA]
- positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [IDA]
- positive regulation of endothelial cell migration [IDA]
- positive regulation of endothelial cell proliferation [IDA, ISS]
- positive regulation of epithelial cell proliferation [ISS]
- positive regulation of focal adhesion assembly [IDA]
- positive regulation of gene expression [IDA]
- positive regulation of histone deacetylase activity [IDA]
- positive regulation of leukocyte migration [TAS]
- positive regulation of mast cell chemotaxis [IDA]
- positive regulation of mesenchymal cell proliferation [ISS]
- positive regulation of neuroblast proliferation [ISS]
- positive regulation of p38MAPK cascade [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of peptidyl-tyrosine autophosphorylation [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of positive chemotaxis [IDA]
- positive regulation of protein autophosphorylation [IDA]
- positive regulation of protein complex assembly [IDA]
- positive regulation of protein kinase C signaling [IDA]
- positive regulation of protein kinase D signaling [IDA]
- positive regulation of protein localization to early endosome [IDA]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of receptor internalization [IDA]
- positive regulation of retinal ganglion cell axon guidance [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [IMP]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [IDA]
- positive regulation of vascular permeability [IDA]
- post-embryonic camera-type eye development [ISS]
- primitive erythrocyte differentiation [ISS]
- regulation of cGMP metabolic process [IDA]
- regulation of cell shape [IDA]
- regulation of retinal ganglion cell axon guidance [ISS]
- regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- response to hypoxia [IDA]
- surfactant homeostasis [ISS]
- tube formation [IDA]
- vascular endothelial growth factor receptor signaling pathway [IDA, TAS]
- vascular endothelial growth factor signaling pathway [IDA]
- vasculogenesis [TAS]
Gene Ontology Molecular Function- chemoattractant activity [IDA]
- cytokine activity [IDA, ISS]
- extracellular matrix binding [IC]
- fibronectin binding [IDA]
- growth factor activity [IDA, ISS]
- heparin binding [IDA, IMP]
- identical protein binding [IPI]
- neuropilin binding [IPI]
- platelet-derived growth factor receptor binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [ISS]
- receptor agonist activity [IPI]
- vascular endothelial growth factor receptor 1 binding [IPI]
- vascular endothelial growth factor receptor 2 binding [IPI]
- vascular endothelial growth factor receptor binding [IPI]
- chemoattractant activity [IDA]
- cytokine activity [IDA, ISS]
- extracellular matrix binding [IC]
- fibronectin binding [IDA]
- growth factor activity [IDA, ISS]
- heparin binding [IDA, IMP]
- identical protein binding [IPI]
- neuropilin binding [IPI]
- platelet-derived growth factor receptor binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [ISS]
- receptor agonist activity [IPI]
- vascular endothelial growth factor receptor 1 binding [IPI]
- vascular endothelial growth factor receptor 2 binding [IPI]
- vascular endothelial growth factor receptor binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Co-purification
An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps.
Publication
Placenta growth factor-1 antagonizes VEGF-induced angiogenesis and tumor growth by the formation of functionally inactive PlGF-1/VEGF heterodimers.
Tumor growth and metastasis require concomitant growth of new blood vessels, which are stimulated by angiogenic factors, including vascular endothelial growth factor (VEGF), secreted by most tumors. Whereas the angiogenic property and molecular mechanisms of VEGF have been well studied, the biological function of its related homolog, placenta growth factor (PlGF), is poorly understood. Here we demonstrate that PlGF-1, an ... [more]
Cancer Cell Feb. 01, 2002; 1(1);99-108 [Pubmed: 12086892]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| VEGFA VEGFA | Co-crystal Structure Co-crystal Structure Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex. | Low | - | BioGRID | - | |
| VEGFA VEGFA | Co-purification Co-purification An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps. | Low | - | BioGRID | - | |
| VEGFA VEGFA | FRET FRET An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins. | Low | - | BioGRID | 2660139 |
Curated By
- BioGRID