NCS1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DRD3
Gene Ontology Biological Process
- G-protein coupled receptor internalization [IDA]
- G-protein coupled receptor signaling pathway [IDA]
- acid secretion [ISS]
- adenylate cyclase-activating dopamine receptor signaling pathway [IDA]
- adenylate cyclase-inhibiting dopamine receptor signaling pathway [IDA]
- arachidonic acid secretion [IDA]
- behavioral response to cocaine [IEP, ISS]
- cellular calcium ion homeostasis [IDA]
- circadian regulation of gene expression [ISS]
- dopamine metabolic process [IC]
- learning [NAS]
- learning or memory [NAS]
- locomotory behavior [ISS]
- musculoskeletal movement, spinal reflex action [ISS]
- negative regulation of adenylate cyclase activity [IDA]
- negative regulation of blood pressure [ISS]
- negative regulation of oligodendrocyte differentiation [ISS]
- negative regulation of protein kinase B signaling [ISS]
- negative regulation of protein secretion [IDA]
- positive regulation of cytokinesis [IMP]
- positive regulation of dopamine receptor signaling pathway [ISS]
- positive regulation of mitosis [ISS]
- prepulse inhibition [IMP]
- regulation of cAMP metabolic process [IDA]
- regulation of dopamine secretion [ISS]
- regulation of dopamine uptake involved in synaptic transmission [IC]
- response to cocaine [IEP]
- response to drug [ISS]
- response to ethanol [ISS]
- response to histamine [IDA]
- response to morphine [ISS]
- social behavior [NAS]
- visual learning [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Interaction with neuronal calcium sensor NCS-1 mediates desensitization of the D2 dopamine receptor.
Dopaminergic transmission within limbic regions of the brain is highly dependent on the regulation of D2 receptor activity. Here we show that the neuronal calcium sensor-1 (NCS-1) can mediate desensitization of D2 dopamine receptors. Analysis of D2 receptors expressed in human embryonic kidney 293 cells indicates that NCS-1 attenuates agonist-induced receptor internalization via a mechanism that involves a reduction in ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID