BAIT
PINK1
BRPK, PARK6
PTEN induced putative kinase 1
GO Process (37)
GO Function (11)
GO Component (17)
Gene Ontology Biological Process
- TORC2 signaling [IC]
- activation of protein kinase B activity [IC]
- cellular response to hypoxia [IMP]
- cellular response to toxic substance [TAS]
- intracellular signal transduction [IDA]
- mitochondrion degradation [IMP]
- mitochondrion organization [IMP]
- negative regulation of JNK cascade [TAS]
- negative regulation of gene expression [ISS]
- negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway [IDA, IMP]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of oxidative stress-induced cell death [IDA]
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [IDA]
- negative regulation of oxidative stress-induced neuron death [TAS]
- negative regulation of reactive oxygen species metabolic process [IMP]
- peptidyl-serine autophosphorylation [TAS]
- peptidyl-serine phosphorylation [IDA, TAS]
- phosphorylation [NAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of mitochondrial electron transport, NADH to ubiquinone [TAS]
- positive regulation of mitochondrial fission [IBA]
- positive regulation of peptidase activity [TAS]
- positive regulation of peptidyl-serine phosphorylation [IDA, TAS]
- positive regulation of protein kinase B signaling [IC]
- positive regulation of release of cytochrome c from mitochondria [IMP]
- positive regulation of ubiquitin-protein transferase activity [TAS]
- protein phosphorylation [IDA, TAS]
- protein ubiquitination [IMP]
- regulation of mitochondrial membrane potential [IGI, IMP]
- regulation of mitochondrion degradation [TAS]
- regulation of protein complex assembly [IDA]
- regulation of protein ubiquitination [IDA]
- regulation of reactive oxygen species metabolic process [IGI, IMP]
- regulation of synaptic vesicle transport [TAS]
- response to oxidative stress [IGI]
- response to stress [IDA]
- ubiquitin-dependent protein catabolic process [TAS]
Gene Ontology Molecular Function- ATP binding [IDA]
- C3HC4-type RING finger domain binding [IPI]
- calcium-dependent protein kinase activity [IDA]
- kinase activity [IDA, NAS]
- magnesium ion binding [IDA]
- peptidase activator activity [TAS]
- protease binding [IPI, TAS]
- protein binding [IPI]
- protein kinase B binding [IDA]
- protein serine/threonine kinase activity [IDA, TAS]
- ubiquitin protein ligase binding [IPI]
- ATP binding [IDA]
- C3HC4-type RING finger domain binding [IPI]
- calcium-dependent protein kinase activity [IDA]
- kinase activity [IDA, NAS]
- magnesium ion binding [IDA]
- peptidase activator activity [TAS]
- protease binding [IPI, TAS]
- protein binding [IPI]
- protein kinase B binding [IDA]
- protein serine/threonine kinase activity [IDA, TAS]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
- Lewy body [TAS]
- TORC2 complex [IPI]
- astrocyte projection [IDA]
- axon [IDA]
- cell body [IDA]
- chromatin [IDA]
- cytoplasm [IDA]
- cytoskeleton [IDA]
- cytosol [IDA]
- integral component of mitochondrial outer membrane [IDA]
- membrane [IDA]
- mitochondrial inner membrane [IDA]
- mitochondrial intermembrane space [IDA]
- mitochondrial outer membrane [IDA]
- mitochondrion [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
Homo sapiens
PREY
MYH9
BDPLT6, DFNA17, EPSTS, FTNS, MHA, NMHC-II-A, NMMHC-IIA, NMMHCA, RP1-68O2.1
myosin, heavy chain 9, non-muscle
GO Process (16)
GO Function (12)
GO Component (20)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- actin cytoskeleton reorganization [IMP]
- actin filament-based movement [IDA]
- actomyosin structure organization [IDA]
- angiogenesis [IDA]
- axon guidance [TAS]
- blood vessel endothelial cell migration [IMP]
- cytokinesis [IMP]
- integrin-mediated signaling pathway [NAS]
- leukocyte migration [NAS]
- membrane protein ectodomain proteolysis [IDA]
- monocyte differentiation [IEP]
- platelet aggregation [IMP]
- platelet formation [IMP]
- protein transport [IMP]
- regulation of cell shape [IMP]
Gene Ontology Molecular Function- ADP binding [IDA]
- ATP binding [IDA]
- ATPase activity [IDA]
- actin binding [IDA]
- actin filament binding [IDA, NAS]
- actin-dependent ATPase activity [IDA]
- microfilament motor activity [IDA]
- motor activity [NAS]
- poly(A) RNA binding [IDA]
- protein anchor [IMP]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- ADP binding [IDA]
- ATP binding [IDA]
- ATPase activity [IDA]
- actin binding [IDA]
- actin filament binding [IDA, NAS]
- actin-dependent ATPase activity [IDA]
- microfilament motor activity [IDA]
- motor activity [NAS]
- poly(A) RNA binding [IDA]
- protein anchor [IMP]
- protein binding [IPI]
- protein homodimerization activity [IDA]
Gene Ontology Cellular Component
- COP9 signalosome [IDA]
- actin cytoskeleton [IDA]
- actomyosin [IDA]
- actomyosin contractile ring [IDA]
- cell leading edge [IDA]
- cleavage furrow [IDA]
- cytoplasm [IDA]
- cytosol [IDA]
- extracellular vesicular exosome [IDA]
- immunological synapse [IDA]
- integrin complex [IDA]
- membrane [IDA]
- myosin II complex [IDA]
- myosin II filament [IDA]
- nucleus [IDA]
- plasma membrane [IDA]
- protein complex [IDA]
- ruffle [IDA]
- stress fiber [IDA]
- uropod [IDA]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.
Maintaining a pool of functional mitochondria requires degradation of damaged ones within the cell. PINK1 is critical in this quality-control process: loss of mitochondrial membrane potential causes PINK1 to accumulate on the mitochondrial surface, triggering mitophagy. However, little is known about how PINK1 is regulated. Recently, we showed that PINK1 content is kept low in healthy mitochondria by continuous ubiquitination ... [more]
J. Neurosci. Dec. 04, 2018; 39(36);7074-7085 [Pubmed: 31300519]
Throughput
- High Throughput
Additional Notes
- assayed using LC-MS/MS (liquid chromatography/tandem mass spectrometry)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PINK1 MYH9 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.3968 | BioGRID | 3225741 |
Curated By
- BioGRID