XBP1
Gene Ontology Biological Process
- adipose tissue development [IMP]
- angiogenesis [IMP]
- cell growth [ISO]
- cellular response to amino acid stimulus [IDA]
- cellular response to fluid shear stress [ISO]
- cellular response to fructose stimulus [IDA]
- cellular response to glucose stimulus [IDA]
- cellular response to insulin stimulus [IDA]
- cellular response to interleukin-4 [IDA]
- cellular response to laminar fluid shear stress [ISO]
- cellular response to lipopolysaccharide [IDA, ISO]
- cellular response to nutrient [IDA]
- cellular response to oxidative stress [ISO]
- cellular response to peptide hormone stimulus [IDA]
- cellular response to vascular endothelial growth factor stimulus [ISO]
- cellular triglyceride homeostasis [IMP]
- cholesterol homeostasis [IMP]
- endoplasmic reticulum unfolded protein response [IDA, ISO]
- endothelial cell proliferation [IMP, ISO]
- epithelial cell maturation [IMP]
- epithelial cell maturation involved in salivary gland development [IMP]
- exocrine pancreas development [IMP]
- fatty acid homeostasis [IMP]
- glucose homeostasis [IDA]
- liver development [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [ISO]
- negative regulation of endoplasmic reticulum unfolded protein response [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- neuron development [IDA]
- phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of B cell differentiation [ISO]
- positive regulation of MHC class II biosynthetic process [ISO]
- positive regulation of T cell differentiation [ISO]
- positive regulation of TOR signaling [ISO]
- positive regulation of autophagy [ISO]
- positive regulation of endoplasmic reticulum unfolded protein response [ISO]
- positive regulation of endothelial cell apoptotic process [ISO]
- positive regulation of fat cell differentiation [IMP]
- positive regulation of hepatocyte proliferation [IMP]
- positive regulation of histone methylation [ISO]
- positive regulation of immunoglobulin production [ISO]
- positive regulation of immunoglobulin secretion [IDA]
- positive regulation of interleukin-6 secretion [IDA]
- positive regulation of lactation [IMP]
- positive regulation of plasma cell differentiation [ISO]
- positive regulation of proteasomal protein catabolic process [IDA]
- positive regulation of protein acetylation [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of transcription factor import into nucleus [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP, ISO]
- positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response [ISO]
- protein destabilization [IMP, ISO]
- regulation of autophagy [IMP]
- regulation of protein stability [ISO]
- regulation of transcription from RNA polymerase II promoter [IDA]
- response to drug [ISO]
- response to electrical stimulus [ISO]
- response to endoplasmic reticulum stress [IDA, ISO]
- serotonin secretion, neurotransmission [ISO]
- sterol homeostasis [IMP]
- transcription from RNA polymerase II promoter [IDA, ISO]
- ubiquitin-dependent protein catabolic process [IMP]
- vascular endothelial growth factor receptor signaling pathway [ISO]
Gene Ontology Molecular Function- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- RNA polymerase II transcription factor binding [IPI]
- chromatin DNA binding [ISO]
- enhancer sequence-specific DNA binding [ISO]
- phosphatidylinositol 3-kinase regulatory subunit binding [IPI]
- protease binding [ISO]
- protein heterodimerization activity [ISO]
- protein kinase binding [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription regulatory region DNA binding [IDA, ISO]
- ubiquitin protein ligase binding [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [ISO]
- RNA polymerase II transcription factor binding [IPI]
- chromatin DNA binding [ISO]
- enhancer sequence-specific DNA binding [ISO]
- phosphatidylinositol 3-kinase regulatory subunit binding [IPI]
- protease binding [ISO]
- protein heterodimerization activity [ISO]
- protein kinase binding [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- sequence-specific DNA binding transcription factor activity [ISO]
- transcription regulatory region DNA binding [IDA, ISO]
- ubiquitin protein ligase binding [ISO]
CUL3
Gene Ontology Biological Process
- COPII vesicle coating [IMP]
- ER to Golgi vesicle-mediated transport [IDA]
- G1/S transition of mitotic cell cycle [TAS]
- cell cycle arrest [TAS]
- cell migration [IMP]
- embryonic cleavage [ISS]
- integrin-mediated signaling pathway [ISS]
- intrinsic apoptotic signaling pathway [TAS]
- mitotic metaphase plate congression [IMP]
- negative regulation of Rho protein signal transduction [IMP]
- negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation [IDA]
- positive regulation of cell proliferation [TAS]
- positive regulation of cytokinesis [IMP]
- positive regulation of mitotic metaphase/anaphase transition [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein monoubiquitination [IDA]
- protein polyubiquitination [IDA]
- protein ubiquitination [IDA]
- stem cell division [ISS]
- stress fiber assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The orphan nuclear receptor SHP regulates ER stress response by inhibiting XBP1s degradation.
The orphan nuclear receptor SHP (small heterodimer partner) is a well-known transcriptional corepressor of bile acid and lipid metabolism in the liver; however, its function in other tissues is poorly understood. Here, we report an unexpected role for SHP in the exocrine pancreas as a modulator of the endoplasmic reticulum (ER) stress response. SHP expression is induced in acinar cells ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CUL3 XBP1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 2753955 |
Curated By
- BioGRID