LRRK2
Gene Ontology Biological Process
- GTP catabolic process [IDA]
- MAPK cascade [IDA]
- activation of MAPK activity [IDA]
- activation of MAPKK activity [IDA]
- cellular protein localization [ISS]
- cellular response to dopamine [IMP]
- cellular response to manganese ion [IMP]
- cellular response to oxidative stress [IMP]
- determination of adult lifespan [IMP]
- endocytosis [IGI, IMP]
- exploration behavior [IMP]
- intracellular distribution of mitochondria [IMP]
- intracellular signal transduction [ISS]
- negative regulation of GTPase activity [IDA]
- negative regulation of hydrogen peroxide-induced cell death [IMP]
- negative regulation of late endosome to lysosome transport [TAS]
- negative regulation of peroxidase activity [IDA]
- negative regulation of protein binding [IMP]
- negative regulation of protein phosphorylation [ISS]
- negative regulation of protein processing [IDA]
- negative regulation of protein processing involved in protein targeting to mitochondrion [IC]
- negative regulation of protein targeting to mitochondrion [IDA]
- negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation [IDA]
- neuromuscular junction development [IMP]
- neuron death [IMP]
- neuron projection morphogenesis [IMP]
- olfactory bulb development [IMP]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA, IMP]
- positive regulation of GTPase activity [IDA]
- positive regulation of MAP kinase activity [IC]
- positive regulation of autophagy [IMP, ISS]
- positive regulation of dopamine receptor signaling pathway [IMP]
- positive regulation of programmed cell death [IDA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISS]
- positive regulation of protein autoubiquitination [IDA]
- positive regulation of protein binding [IDA]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of protein ubiquitination [IDA]
- protein autophosphorylation [IDA, IMP]
- protein localization to mitochondrion [TAS]
- protein phosphorylation [IMP]
- reactive oxygen species metabolic process [IMP]
- regulation of branching morphogenesis of a nerve [IMP]
- regulation of dendritic spine morphogenesis [IMP, ISS]
- regulation of dopamine receptor signaling pathway [ISS]
- regulation of excitatory postsynaptic membrane potential [ISS]
- regulation of kidney size [ISS]
- regulation of locomotion [IMP]
- regulation of membrane potential [IMP]
- regulation of mitochondrial depolarization [IMP]
- regulation of mitochondrial fission [TAS]
- regulation of neuroblast proliferation [IMP]
- regulation of neuron death [IMP]
- regulation of neuron maturation [IMP]
- regulation of protein kinase A signaling [ISS]
- regulation of synaptic transmission, glutamatergic [ISS]
- regulation of synaptic vesicle exocytosis [IMP]
- regulation of synaptic vesicle transport [ISS, TAS]
- response to oxidative stress [IMP]
- tangential migration from the subventricular zone to the olfactory bulb [IMP]
Gene Ontology Molecular Function- GTP binding [IDA]
- GTP-dependent protein kinase activity [IDA, IMP]
- GTPase activator activity [IDA]
- GTPase activity [IDA]
- MAP kinase kinase activity [IDA]
- Rho GTPase binding [IPI]
- SNARE binding [IPI]
- actin binding [IPI]
- clathrin binding [IPI]
- glycoprotein binding [IPI]
- identical protein binding [IPI]
- ion channel binding [IPI]
- kinase activity [IDA]
- peroxidase inhibitor activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- protein kinase A binding [IPI]
- protein kinase activity [IDA]
- protein serine/threonine kinase activity [IDA]
- syntaxin-1 binding [IPI]
- tubulin binding [IDA]
- GTP binding [IDA]
- GTP-dependent protein kinase activity [IDA, IMP]
- GTPase activator activity [IDA]
- GTPase activity [IDA]
- MAP kinase kinase activity [IDA]
- Rho GTPase binding [IPI]
- SNARE binding [IPI]
- actin binding [IPI]
- clathrin binding [IPI]
- glycoprotein binding [IPI]
- identical protein binding [IPI]
- ion channel binding [IPI]
- kinase activity [IDA]
- peroxidase inhibitor activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- protein kinase A binding [IPI]
- protein kinase activity [IDA]
- protein serine/threonine kinase activity [IDA]
- syntaxin-1 binding [IPI]
- tubulin binding [IDA]
Gene Ontology Cellular Component
- Golgi apparatus [ISS]
- axon [IDA, ISS]
- cytoplasm [IDA]
- cytoplasmic side of mitochondrial outer membrane [IDA]
- cytoplasmic vesicle [ISS]
- cytosol [IDA]
- dendrite [IDA, ISS]
- dendrite cytoplasm [IDA]
- endoplasmic reticulum [ISS]
- endosome [ISS]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- inclusion body [IMP]
- lysosome [ISS]
- mitochondrial inner membrane [ISS]
- mitochondrial matrix [ISS]
- mitochondrial membrane [IDA]
- mitochondrial outer membrane [ISS]
- mitochondrion [IDA]
- neuron projection [IDA]
- neuronal cell body [IDA]
- perikaryon [IDA, ISS]
- terminal bouton [TAS]
EIF4EBP1
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IMP]
- TOR signaling [IDA]
- cellular protein metabolic process [TAS]
- gene expression [TAS]
- insulin receptor signaling pathway [TAS]
- negative regulation of translational initiation [IDA]
- positive regulation of mitotic cell cycle [IMP]
- translation [TAS]
- translational initiation [TAS]
Gene Ontology Molecular Function
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Phosphorylation of 4E-BP1 in the mammalian brain is not altered by LRRK2 expression or pathogenic mutations.
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are a common cause of autosomal dominant familial Parkinson's disease (PD). LRRK2 encodes a multi-domain protein containing GTPase and kinase enzymatic domains. Disease-associated mutations in LRRK2 variably influence enzymatic activity with the common G2019S variant leading to enhanced kinase activity. Mutant LRRK2 induces neuronal toxicity through a kinase-dependent mechanism suggesting that ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| LRRK2 EIF4EBP1 | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 723233 | |
| LRRK2 EIF4EBP1 | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 722864 |
Curated By
- BioGRID