BAIT
ENG
END, HHT1, ORW1, RP11-228B15.2
endoglin
GO Process (35)
GO Function (11)
GO Component (7)
Gene Ontology Biological Process
- BMP signaling pathway [TAS]
- artery morphogenesis [ISS]
- cell chemotaxis [IMP]
- cell migration [IMP]
- cell motility [IMP]
- central nervous system vasculogenesis [IMP]
- chronological cell aging [IEP]
- detection of hypoxia [IDA]
- extracellular matrix disassembly [IMP]
- heart looping [ISS]
- intracellular signal transduction [IDA]
- negative regulation of cell migration [IDA]
- negative regulation of endothelial cell proliferation [IMP]
- negative regulation of nitric-oxide synthase activity [IMP]
- negative regulation of pathway-restricted SMAD protein phosphorylation [IMP]
- negative regulation of protein autophosphorylation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- patterning of blood vessels [ISS]
- positive regulation of BMP signaling pathway [IDA]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IDA, IMP]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of systemic arterial blood pressure [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of cell adhesion [TAS]
- regulation of cell proliferation [TAS]
- regulation of phosphorylation [TAS]
- regulation of transcription, DNA-templated [IMP]
- regulation of transforming growth factor beta receptor signaling pathway [IDA]
- response to hypoxia [IDA]
- smooth muscle tissue development [ISS]
- transforming growth factor beta receptor signaling pathway [IDA]
- vasculogenesis [IMP]
- venous blood vessel morphogenesis [ISS]
- wound healing [IMP]
Gene Ontology Molecular Function- activin binding [TAS]
- galactose binding [IDA]
- glycosaminoglycan binding [IDA, ISS]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- transforming growth factor beta binding [IPI]
- transforming growth factor beta receptor, cytoplasmic mediator activity [IDA]
- transforming growth factor beta-activated receptor activity [IDA]
- transmembrane signaling receptor activity [NAS]
- type I transforming growth factor beta receptor binding [IPI, ISS]
- type II transforming growth factor beta receptor binding [IPI, ISS]
- activin binding [TAS]
- galactose binding [IDA]
- glycosaminoglycan binding [IDA, ISS]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- transforming growth factor beta binding [IPI]
- transforming growth factor beta receptor, cytoplasmic mediator activity [IDA]
- transforming growth factor beta-activated receptor activity [IDA]
- transmembrane signaling receptor activity [NAS]
- type I transforming growth factor beta receptor binding [IPI, ISS]
- type II transforming growth factor beta receptor binding [IPI, ISS]
Gene Ontology Cellular Component
Homo sapiens
PREY
CSNK1D
ASPS, CKIdelta, FASPS2, HCKID
casein kinase 1, delta
GO Process (14)
GO Function (3)
GO Component (8)
Gene Ontology Biological Process
- DNA repair [TAS]
- G2/M transition of mitotic cell cycle [TAS]
- circadian regulation of gene expression [ISS]
- endocytosis [IBA]
- mitotic cell cycle [TAS]
- peptidyl-serine phosphorylation [IBA]
- positive regulation of canonical Wnt signaling pathway [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISS]
- positive regulation of protein phosphorylation [IMP]
- protein phosphorylation [IDA]
- regulation of cell shape [IBA]
- regulation of circadian rhythm [ISS]
- signal transduction [TAS]
- spindle assembly [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Endoglin Protein Interactome Profiling Identifies TRIM21 and Galectin-3 as New Binding Partners.
Endoglin is a 180-kDa glycoprotein receptor primarily expressed by the vascular endothelium and involved in cardiovascular disease and cancer. Heterozygous mutations in the endoglin gene (ENG) cause hereditary hemorrhagic telangiectasia type 1, a vascular disease that presents with nasal and gastrointestinal bleeding, skin and mucosa telangiectases, and arteriovenous malformations in internal organs. A circulating form of endoglin (alias soluble endoglin, ... [more]
Cells Dec. 13, 2018; 8(9); [Pubmed: 31540324]
Throughput
- High Throughput
Curated By
- BioGRID