BAIT
LCK
IMD22, LSK, YT16, p56lck, pp58lck, RP4-675E8.4
LCK proto-oncogene, Src family tyrosine kinase
GO Process (30)
GO Function (14)
GO Component (7)
Gene Ontology Biological Process
- B cell receptor signaling pathway [IBA]
- Fc-epsilon receptor signaling pathway [TAS]
- T cell costimulation [TAS]
- T cell differentiation [IMP, ISS]
- T cell receptor signaling pathway [TAS]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA, ISS]
- blood coagulation [TAS]
- cellular response to peptide hormone stimulus [IBA]
- cellular zinc ion homeostasis [IEP, ISS]
- dephosphorylation [IDA, ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- hemopoiesis [NAS]
- innate immune response [IBA, TAS]
- leukocyte migration [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine autophosphorylation [IBA]
- phosphatidylinositol-mediated signaling [TAS]
- platelet activation [TAS]
- positive regulation of T cell activation [IDA, ISS]
- positive regulation of T cell receptor signaling pathway [NAS]
- positive regulation of intrinsic apoptotic signaling pathway [IMP, ISS]
- protein phosphorylation [IDA]
- regulation of cell proliferation [IBA]
- regulation of defense response to virus by virus [TAS]
- regulation of lymphocyte activation [NAS]
- release of sequestered calcium ion into cytosol [ISS]
- response to drug [IDA, ISS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
- viral process [TAS]
Gene Ontology Molecular Function- ATPase binding [IPI]
- CD4 receptor binding [IPI]
- CD8 receptor binding [IPI]
- SH2 domain binding [IPI, ISS]
- glycoprotein binding [IPI]
- identical protein binding [IPI]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- phosphatidylinositol 3-kinase binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein phosphatase binding [IPI]
- protein serine/threonine phosphatase activity [IDA, ISS]
- protein tyrosine kinase activity [EXP, IDA, ISS, TAS]
- ATPase binding [IPI]
- CD4 receptor binding [IPI]
- CD8 receptor binding [IPI]
- SH2 domain binding [IPI, ISS]
- glycoprotein binding [IPI]
- identical protein binding [IPI]
- non-membrane spanning protein tyrosine kinase activity [IBA]
- phosphatidylinositol 3-kinase binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein phosphatase binding [IPI]
- protein serine/threonine phosphatase activity [IDA, ISS]
- protein tyrosine kinase activity [EXP, IDA, ISS, TAS]
Gene Ontology Cellular Component
Homo sapiens
PREY
PTK2B
CADTK, CAKB, FADK2, FAK2, PKB, PTK, PYK2, RAFTK
protein tyrosine kinase 2 beta
GO Process (53)
GO Function (7)
GO Component (15)
Gene Ontology Biological Process
- activation of Janus kinase activity [IMP]
- angiogenesis [IBA]
- apoptotic process [TAS]
- bone resorption [ISS]
- cell surface receptor signaling pathway [IMP]
- cellular defense response [ISS]
- cellular response to retinoic acid [IMP]
- chemokine-mediated signaling pathway [ISS]
- epidermal growth factor receptor signaling pathway [IBA]
- innate immune response [IBA]
- integrin-mediated signaling pathway [IMP]
- ionotropic glutamate receptor signaling pathway [ISS]
- long-term synaptic potentiation [ISS]
- marginal zone B cell differentiation [ISS]
- negative regulation of apoptotic process [IMP]
- negative regulation of bone mineralization [ISS]
- negative regulation of cell proliferation [IMP]
- negative regulation of myeloid cell differentiation [IMP]
- negative regulation of neuron apoptotic process [ISS]
- negative regulation of potassium ion transport [IDA]
- peptidyl-tyrosine autophosphorylation [IBA, ISS]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of B cell chemotaxis [ISS]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of JNK cascade [IMP]
- positive regulation of actin filament polymerization [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [IMP]
- positive regulation of cell-matrix adhesion [IMP]
- positive regulation of endothelial cell migration [IDA]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- positive regulation of neuron projection development [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of phosphatidylinositol 3-kinase activity [ISS]
- positive regulation of protein kinase activity [IMP]
- positive regulation of synaptic transmission, glutamatergic [ISS]
- protein autophosphorylation [TAS]
- protein complex assembly [TAS]
- protein phosphorylation [TAS]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISS]
- regulation of actin cytoskeleton reorganization [ISS]
- regulation of cell adhesion [IMP]
- regulation of cell shape [IMP]
- regulation of establishment of cell polarity [ISS]
- regulation of inositol trisphosphate biosynthetic process [ISS]
- regulation of macrophage chemotaxis [ISS]
- regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]
- regulation of release of sequestered calcium ion into cytosol [ISS]
- response to stress [TAS]
- signal transduction [TAS]
- sprouting angiogenesis [ISS]
- tumor necrosis factor-mediated signaling pathway [IMP]
- vascular endothelial growth factor receptor signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [ISS]
- apical dendrite [ISS]
- cell body [ISS]
- cytoplasm [IDA]
- cytosol [TAS]
- dendrite [ISS]
- extrinsic component of cytoplasmic side of plasma membrane [IBA]
- focal adhesion [IDA]
- growth cone [ISS]
- lamellipodium [IDA]
- neuronal cell body [ISS]
- nucleoplasm [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [IDA]
- postsynaptic density [ISS]
Homo sapiens
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
RAFTK, a novel member of the focal adhesion kinase family, is phosphorylated and associates with signaling molecules upon activation of mature T lymphocytes.
The related adhesion focal tyrosine kinase (RAFTK), a recently discovered member of the focal adhesion kinase family, has previously been reported to participate in signal transduction in neuronal cells, megakaryocytes, and B lymphocytes. We have found that RAFTK is constitutively expressed in human T cells and is rapidly phosphorylated upon the activation of the T cell receptor (TCR). This activation ... [more]
J. Exp. Med. Mar. 17, 1997; 185(6);1055-63 [Pubmed: 9091579]
Throughput
- Low Throughput
Curated By
- BioGRID