PIK3R1
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- T cell costimulation [TAS]
- T cell receptor signaling pathway [TAS]
- blood coagulation [TAS]
- cellular glucose homeostasis [ISS]
- cellular response to insulin stimulus [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- growth hormone receptor signaling pathway [IDA]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- insulin-like growth factor receptor signaling pathway [IDA, IPI]
- leukocyte migration [TAS]
- negative regulation of apoptotic process [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol 3-kinase signaling [IDA]
- phosphatidylinositol biosynthetic process [TAS]
- phosphatidylinositol phosphorylation [ISS]
- phosphatidylinositol-mediated signaling [TAS]
- phospholipid metabolic process [TAS]
- platelet activation [TAS]
- positive regulation of RNA splicing [IMP]
- positive regulation of endoplasmic reticulum unfolded protein response [IMP]
- positive regulation of establishment of protein localization to plasma membrane [ISS]
- positive regulation of glucose import [ISS]
- positive regulation of transcription factor import into nucleus [IDA, ISS]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISS]
- protein stabilization [IDA]
- regulation of phosphatidylinositol 3-kinase activity [ISS]
- response to endoplasmic reticulum stress [IDA, ISS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function- ErbB-3 class receptor binding [IDA]
- insulin binding [IDA]
- insulin receptor binding [IPI]
- insulin receptor substrate binding [ISS]
- insulin-like growth factor receptor binding [IPI]
- neurotrophin TRKA receptor binding [IPI]
- phosphatidylinositol 3-kinase binding [ISS]
- phosphatidylinositol 3-kinase regulator activity [ISS]
- protein binding [IPI]
- protein phosphatase binding [IPI]
- transcription factor binding [IPI]
- transmembrane receptor protein tyrosine kinase adaptor activity [ISS]
- ErbB-3 class receptor binding [IDA]
- insulin binding [IDA]
- insulin receptor binding [IPI]
- insulin receptor substrate binding [ISS]
- insulin-like growth factor receptor binding [IPI]
- neurotrophin TRKA receptor binding [IPI]
- phosphatidylinositol 3-kinase binding [ISS]
- phosphatidylinositol 3-kinase regulator activity [ISS]
- protein binding [IPI]
- protein phosphatase binding [IPI]
- transcription factor binding [IPI]
- transmembrane receptor protein tyrosine kinase adaptor activity [ISS]
Gene Ontology Cellular Component
PRMT8
Gene Ontology Biological Process
Gene Ontology Molecular Function- S-adenosylmethionine-dependent methyltransferase activity [IDA]
- histone methyltransferase activity (H4-R3 specific) [IBA]
- histone-arginine N-methyltransferase activity [IDA]
- identical protein binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA]
- protein-arginine omega-N asymmetric methyltransferase activity [IDA]
- protein-arginine omega-N monomethyltransferase activity [IDA]
- S-adenosylmethionine-dependent methyltransferase activity [IDA]
- histone methyltransferase activity (H4-R3 specific) [IBA]
- histone-arginine N-methyltransferase activity [IDA]
- identical protein binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA]
- protein-arginine omega-N asymmetric methyltransferase activity [IDA]
- protein-arginine omega-N monomethyltransferase activity [IDA]
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain.
Human protein arginine methyltransferase PRMT8 has been recently described as a type I enzyme in brain that is localized to the plasma membrane by N-terminal myristoylation. The amino acid sequence of human PRMT8 is almost 80% identical to human PRMT1, the major protein arginine methyltransferase activity in mammalian cells. However, the activity of a recombinant PRMT8 GST fusion protein toward ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID