BAIT
BRAF
B-RAF1, BRAF1, NS7, RAFB1
B-Raf proto-oncogene, serine/threonine kinase
GO Process (12)
GO Function (6)
GO Component (2)
Gene Ontology Biological Process
- activation of MAPKK activity [TAS]
- cellular response to calcium ion [IDA]
- fibroblast growth factor receptor signaling pathway [TAS]
- negative regulation of apoptotic process [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- organ morphogenesis [TAS]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of gene expression [IMP]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- protein phosphorylation [IDA]
- small GTPase mediated signal transduction [TAS]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PSMC4
MIP224, RPT3, S6, TBP-7, TBP7
proteasome (prosome, macropain) 26S subunit, ATPase, 4
GO Process (23)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- ATP catabolic process [TAS]
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [TAS]
- G1/S transition of mitotic cell cycle [TAS]
- RNA metabolic process [TAS]
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- apoptotic process [TAS]
- cellular nitrogen compound metabolic process [TAS]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- mitotic cell cycle [TAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- protein polyubiquitination [TAS]
- proteolysis [TAS]
- regulation of apoptotic process [TAS]
- regulation of cellular amino acid metabolic process [TAS]
- regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- small molecule metabolic process [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D.
Protein-protein-interaction networks (PPINs) organize fundamental biological processes, but how oncogenic mutations impact these interactions and their functions at a network-level scale is poorly understood. Here, we analyze how a common oncogenic KRAS mutation (KRASG13D) affects PPIN structure and function of the Epidermal Growth Factor Receptor (EGFR) network in colorectal cancer (CRC) cells. Mapping >6000 PPIs shows that this network is ... [more]
Nat Commun Dec. 24, 2019; 11(1);499 [Pubmed: 31980649]
Throughput
- High Throughput
Curated By
- BioGRID