BAIT
LRP1
A2MR, APOER, APR, CD91, IGFBP3R, LRP, LRP1A, TGFBR5
low density lipoprotein receptor-related protein 1
GO Process (14)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- aorta morphogenesis [ISS]
- apoptotic cell clearance [ISS]
- beta-amyloid clearance [TAS]
- lipoprotein transport [NAS]
- negative regulation of Wnt signaling pathway [ISS]
- negative regulation of platelet-derived growth factor receptor-beta signaling pathway [ISS]
- negative regulation of smooth muscle cell migration [ISS]
- phototransduction, visible light [TAS]
- positive regulation of cholesterol efflux [ISS]
- positive regulation of lipid transport [ISS]
- regulation of actin cytoskeleton organization [ISS]
- regulation of cholesterol transport [ISS]
- regulation of phospholipase A2 activity [ISS]
- retinoid metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PDGFB
IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis, LL22NC03-10C3.2
platelet-derived growth factor beta polypeptide
GO Process (60)
GO Function (10)
GO Component (8)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- activation of protein kinase B activity [IDA]
- activation of protein kinase activity [IDA]
- blood coagulation [TAS]
- cell chemotaxis [IDA]
- cellular response to growth factor stimulus [IDA]
- cellular response to mycophenolic acid [ISS]
- embryonic placenta development [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- extracellular matrix organization [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- heart development [ISS]
- hemopoiesis [IMP]
- innate immune response [TAS]
- metanephric glomerular mesangial cell development [ISS]
- monocyte chemotaxis [IDA]
- negative regulation of phosphatidylinositol biosynthetic process [IDA]
- negative regulation of platelet activation [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- paracrine signaling [ISS]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-tyrosine phosphorylation [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- platelet-derived growth factor receptor signaling pathway [IDA]
- positive chemotaxis [IDA]
- positive regulation of DNA biosynthetic process [IDA]
- positive regulation of DNA replication [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of MAPK cascade [IMP]
- positive regulation of blood vessel endothelial cell migration [IDA]
- positive regulation of calcium ion import [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [IDA]
- positive regulation of chemotaxis [IDA]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- positive regulation of endothelial cell proliferation [IDA]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of glomerular filtration [ISS]
- positive regulation of glomerular mesangial cell proliferation [IDA]
- positive regulation of hyaluronan biosynthetic process [IDA]
- positive regulation of metanephric mesenchymal cell migration [IDA]
- positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway [IDA]
- positive regulation of mitosis [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of phosphatidylinositol 3-kinase activity [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [IDA]
- positive regulation of protein autophosphorylation [IDA]
- positive regulation of protein tyrosine kinase activity [IDA]
- positive regulation of reactive oxygen species metabolic process [IDA]
- positive regulation of smooth muscle cell migration [IDA]
- positive regulation of smooth muscle cell proliferation [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein phosphorylation [IDA]
- reactive oxygen species metabolic process [IMP]
- response to wounding [IDA, NAS]
- transforming growth factor beta receptor signaling pathway [ISS]
Gene Ontology Molecular Function- chemoattractant activity [IDA]
- collagen binding [IDA]
- growth factor activity [IDA]
- identical protein binding [IPI]
- platelet-derived growth factor binding [IPI]
- platelet-derived growth factor receptor binding [IDA, IPI, NAS]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IDA]
- superoxide-generating NADPH oxidase activator activity [IDA]
- chemoattractant activity [IDA]
- collagen binding [IDA]
- growth factor activity [IDA]
- identical protein binding [IPI]
- platelet-derived growth factor binding [IPI]
- platelet-derived growth factor receptor binding [IDA, IPI, NAS]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein homodimerization activity [IDA]
- superoxide-generating NADPH oxidase activator activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of the low density lipoprotein receptor-related protein (LRP). Evidence for integrated co-receptor function betwenn LRP and the PDGF.
The low density lipoprotein receptor-related protein (LRP) functions in the catabolism of numerous ligands including proteinases, proteinase inhibitor complexes, and lipoproteins. In the current study we provide evidence indicating an expanded role for LRP in modulating cellular signaling events. Our results show that platelet-derived growth factor (PDGF) BB induces a transient tyrosine phosphorylation of the LRP cytoplasmic domain in a ... [more]
J. Biol. Chem. May. 03, 2002; 277(18);15499-506 [Pubmed: 11854294]
Throughput
- Low Throughput
Curated By
- BioGRID