BAIT
MECR
CGI-63, FASN2B, NRBF1, RP11-467D18.1
mitochondrial trans-2-enoyl-CoA reductase
GO Process (1)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PPARA
4933429D07Rik, AW742785, Nr1c1, PPAR-alpha, PPARalpha, Ppar
peroxisome proliferator activated receptor alpha
GO Process (35)
GO Function (21)
GO Component (1)
Gene Ontology Biological Process
- behavioral response to nicotine [ISO]
- circadian regulation of gene expression [IDA]
- enamel mineralization [IMP]
- epidermis development [IMP]
- fatty acid metabolic process [IMP, ISO, TAS]
- glucose metabolic process [TAS]
- intracellular receptor signaling pathway [ISO]
- lipid metabolic process [TAS]
- lipoprotein metabolic process [ISO]
- negative regulation of appetite [IMP]
- negative regulation of blood pressure [ISO]
- negative regulation of cholesterol storage [ISO]
- negative regulation of macrophage derived foam cell differentiation [ISO]
- negative regulation of neuron death [ISO]
- negative regulation of protein binding [ISO]
- negative regulation of receptor biosynthetic process [ISO]
- negative regulation of sequestering of triglyceride [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription regulatory region DNA binding [ISO]
- positive regulation of fatty acid oxidation [IMP]
- positive regulation of gluconeogenesis [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription, DNA-templated [IMP, ISO]
- regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of circadian rhythm [IDA]
- regulation of fatty acid metabolic process [IMP]
- regulation of gene expression [IMP]
- regulation of glycolytic by positive regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transcription, DNA-templated [ISO, TAS]
- response to hypoxia [ISO]
- response to insulin [ISO]
- steroid hormone mediated signaling pathway [ISO]
- transcription from RNA polymerase II promoter [IDA]
- wound healing [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- MDM2/MDM4 family protein binding [ISO]
- NFAT protein binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II repressing transcription factor binding [ISO]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IDA]
- drug binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- lipid binding [IDA, ISO]
- phosphatase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [ISO]
- protein heterodimerization activity [TAS]
- receptor activity [IDA]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IMP, ISO]
- steroid hormone receptor activity [ISO, TAS]
- ubiquitin conjugating enzyme binding [ISO]
- DNA binding [IDA]
- MDM2/MDM4 family protein binding [ISO]
- NFAT protein binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- RNA polymerase II repressing transcription factor binding [ISO]
- RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription [IDA]
- drug binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- lipid binding [IDA, ISO]
- phosphatase binding [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein domain specific binding [ISO]
- protein heterodimerization activity [TAS]
- receptor activity [IDA]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IMP, ISO]
- steroid hormone receptor activity [ISO, TAS]
- ubiquitin conjugating enzyme binding [ISO]
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Nuclear receptor binding factor-1 (NRBF-1), a protein interacting with a wide spectrum of nuclear hormone receptors.
To identify the proteins which may modulate the functions of peroxisome proliferator-activated receptor (PPAR), a rat liver cDNA library was screened by a yeast two-hybrid system, using the mouse PPARalpha as a bait. A protein named nuclear receptor binding factor-1 (NRBF-1) was identified, which interacts not only with PPARalpha, but also with various nuclear hormone receptors in the presence of ... [more]
Gene Oct. 23, 1998; 221(2);225-33 [Pubmed: 9795230]
Throughput
- Low Throughput
Curated By
- BioGRID