BAIT
MECR
CGI-63, FASN2B, NRBF1, RP11-467D18.1
mitochondrial trans-2-enoyl-CoA reductase
GO Process (1)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HNF4A
Hnf4, Hnf4alpha
hepatocyte nuclear factor 4, alpha
GO Process (37)
GO Function (18)
GO Component (3)
Gene Ontology Biological Process
- SMAD protein signal transduction [ISO]
- acyl-CoA metabolic process [IDA]
- blood coagulation [ISO]
- cell differentiation [IMP]
- cell-cell junction organization [IDA]
- establishment of tissue polarity [IDA]
- glucose homeostasis [ISO]
- lipid homeostasis [ISO]
- lipid metabolic process [ISO]
- negative regulation of activation of JAK2 kinase activity [IDA]
- negative regulation of cell growth [ISO]
- negative regulation of cell proliferation [IDA, ISO]
- negative regulation of mitotic cell cycle [IDA]
- negative regulation of protein import into nucleus, translocation [IDA]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of tyrosine phosphorylation of Stat5 protein [IDA]
- ornithine metabolic process [ISO]
- phospholipid homeostasis [ISO]
- positive regulation of cholesterol homeostasis [ISO]
- positive regulation of fatty acid biosynthetic process [IMP]
- positive regulation of gluconeogenesis [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- regulation of gastrulation [ISO]
- regulation of insulin secretion [ISO]
- regulation of lipid metabolic process [ISO]
- regulation of microvillus assembly [IMP]
- regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transcription, DNA-templated [IDA, ISO]
- response to cAMP [IEP]
- response to drug [IEP]
- response to glucose [IDA, ISO]
- sex differentiation [ISO]
- signal transduction involved in regulation of gene expression [ISO]
- transcription from RNA polymerase II promoter [ISO]
- triglyceride homeostasis [ISO]
- xenobiotic metabolic process [ISO]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- fatty acid binding [IPI, ISO]
- fatty-acyl-CoA binding [IPI]
- palmitoyl-CoA hydrolase activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IMP, ISO]
- receptor binding [ISO]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding [IMP, ISO]
- sequence-specific DNA binding transcription factor activity [IMP, ISO, TAS]
- steroid hormone receptor activity [TAS]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [ISO]
- DNA binding [IDA, ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISO]
- fatty acid binding [IPI, ISO]
- fatty-acyl-CoA binding [IPI]
- palmitoyl-CoA hydrolase activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IMP, ISO]
- receptor binding [ISO]
- repressing transcription factor binding [IPI]
- sequence-specific DNA binding [IMP, ISO]
- sequence-specific DNA binding transcription factor activity [IMP, ISO, TAS]
- steroid hormone receptor activity [TAS]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [ISO]
Rattus norvegicus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Nuclear receptor binding factor-1 (NRBF-1), a protein interacting with a wide spectrum of nuclear hormone receptors.
To identify the proteins which may modulate the functions of peroxisome proliferator-activated receptor (PPAR), a rat liver cDNA library was screened by a yeast two-hybrid system, using the mouse PPARalpha as a bait. A protein named nuclear receptor binding factor-1 (NRBF-1) was identified, which interacts not only with PPARalpha, but also with various nuclear hormone receptors in the presence of ... [more]
Gene Oct. 23, 1998; 221(2);225-33 [Pubmed: 9795230]
Throughput
- Low Throughput
Curated By
- BioGRID