BAIT
DAB2
DOC-2, DOC2
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
GO Process (23)
GO Function (5)
GO Component (9)
Gene Ontology Biological Process
- cell proliferation [TAS]
- integrin-mediated signaling pathway [IMP]
- leading edge cell differentiation [IMP]
- membrane organization [TAS]
- negative regulation of androgen receptor signaling pathway [IMP]
- negative regulation of apoptotic process [IDA]
- negative regulation of canonical Wnt signaling pathway [IMP]
- negative regulation of protein binding [IMP]
- negative regulation of protein localization to plasma membrane [IMP]
- negative regulation of transcription, DNA-templated [IMP]
- positive regulation of SMAD protein import into nucleus [IDA]
- positive regulation of Wnt signaling pathway, planar cell polarity pathway [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of clathrin-mediated endocytosis [IMP]
- positive regulation of early endosome to late endosome transport [IMP]
- positive regulation of endocytosis [IMP]
- positive regulation of epithelial to mesenchymal transition [IDA]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IDA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of transcription, DNA-templated [IMP]
- positive regulation of transforming growth factor beta receptor signaling pathway [IDA]
- receptor-mediated endocytosis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
LRP1
A2MR, APOER, APR, CD91, IGFBP3R, LRP, LRP1A, TGFBR5
low density lipoprotein receptor-related protein 1
GO Process (14)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- aorta morphogenesis [ISS]
- apoptotic cell clearance [ISS]
- beta-amyloid clearance [TAS]
- lipoprotein transport [NAS]
- negative regulation of Wnt signaling pathway [ISS]
- negative regulation of platelet-derived growth factor receptor-beta signaling pathway [ISS]
- negative regulation of smooth muscle cell migration [ISS]
- phototransduction, visible light [TAS]
- positive regulation of cholesterol efflux [ISS]
- positive regulation of lipid transport [ISS]
- regulation of actin cytoskeleton organization [ISS]
- regulation of cholesterol transport [ISS]
- regulation of phospholipase A2 activity [ISS]
- retinoid metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2.
Disabled-2 (Dab2) is a widely expressed relative of Disabled-1, a neuron-specific signal-transduction protein that binds to and receives signals from members of the low-density lipoprotein receptor (LDLR) family. Members of the LDLR family internalize through clathrin-coated pits and vesicles to endosomes, from where they return to the cell surface through the secretory pathway. In this study, we show that the ... [more]
Traffic Feb. 01, 2001; 2(2);111-23 [Pubmed: 11247302]
Throughput
- Low Throughput
Curated By
- BioGRID