BAIT
CCL21
6Ckine, CKb9, ECL, SCYA21, SLC, TCA4, RP11-195F19.22-001
chemokine (C-C motif) ligand 21
GO Process (37)
GO Function (3)
GO Component (1)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA]
- T cell costimulation [ISS]
- activation of Rho GTPase activity [IDA]
- cell chemotaxis [IDA]
- cell maturation [ISS]
- cell-cell signaling [TAS]
- dendritic cell chemotaxis [IDA]
- dendritic cell dendrite assembly [ISS]
- establishment of T cell polarity [IDA]
- immunological synapse formation [ISS]
- inflammatory response [NAS]
- mesangial cell-matrix adhesion [IDA]
- negative regulation of dendritic cell dendrite assembly [ISS]
- negative regulation of leukocyte apoptotic process [IDA]
- negative regulation of leukocyte tethering or rolling [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of JNK cascade [IDA]
- positive regulation of T cell migration [IDA]
- positive regulation of actin filament polymerization [IDA]
- positive regulation of cell adhesion mediated by integrin [IDA]
- positive regulation of cell motility [IDA]
- positive regulation of cell-matrix adhesion [IDA]
- positive regulation of chemotaxis [ISS]
- positive regulation of dendritic cell antigen processing and presentation [ISS]
- positive regulation of filopodium assembly [IDA]
- positive regulation of glycoprotein biosynthetic process [ISS]
- positive regulation of myeloid dendritic cell chemotaxis [IDA]
- positive regulation of neutrophil chemotaxis [IDA]
- positive regulation of phosphatidylinositol 3-kinase activity [IDA]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of protein kinase activity [IDA]
- positive regulation of pseudopodium assembly [IDA]
- positive regulation of receptor-mediated endocytosis [ISS]
- release of sequestered calcium ion into cytosol [IDA]
- response to prostaglandin E [IDA]
- ruffle organization [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
HNRNPA2B1
HNRNPA2, HNRNPB1, HNRPA2, HNRPA2B1, HNRPB1, IBMPFD2, RNPA2, SNRPB1
heterogeneous nuclear ribonucleoprotein A2/B1
GO Process (5)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Proximity Label-MS
An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.
Publication
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei.
Cells organize their actions partly through tightly controlled protein-protein interactions-collectively termed the interactome. Here we use crosslinking mass spectrometry (XL-MS) to chart the protein-protein interactions in intact human nuclei. Overall, we identified ∼8,700 crosslinks, of which 2/3 represent links connecting distinct proteins. From these data, we gain insights on interactions involving histone proteins. We observed that core histones on the ... [more]
Mol. Cell Proteomics Dec. 01, 2017; 17(10);2018-2033 [Pubmed: 30021884]
Throughput
- High Throughput
Additional Notes
- interaction identified using XL-MS (cross-linking mass spectrometry): lysates from unfractionated cells were treated with cross-linker and cross-linked proteins were identified by mass-spectrometry; interaction is undirectional; therefore bait and prey/hit have been assigned arbitrarily; interactions with FDRs (false discovery rates) of 1% or less were reported; this interaction was not detected in parallel experiments using TX100-soluble or TX100-insoluble fractions
Curated By
- BioGRID