BAIT

ADORA1

RDC7

adenosine A1 receptor

GO Process (6)

GO Function (1)

GO Component (2)

Gene Ontology Biological Process

apoptotic signaling pathway [TAS]

cell-cell signaling [TAS]

inflammatory response [TAS]

nervous system development [TAS]

phagocytosis [TAS]

signal transduction [TAS]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

integral component of plasma membrane [TAS]

plasma membrane [TAS]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

PREY

DRD1

DADR, DRD1A

dopamine receptor D1

Alzheimer's Disease Project

Cell Cycle - Mitotic Spindle Assembly Project

GO Process (22)

GO Function (4)

GO Component (2)

Gene Ontology Biological Process

G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [IDA]

activation of adenylate cyclase activity [IDA]

adenylate cyclase-activating G-protein coupled receptor signaling pathway [IDA]

adenylate cyclase-activating dopamine receptor signaling pathway [IDA]

adult walking behavior [ISS]

cellular response to catecholamine stimulus [IDA]

cerebral cortex GABAergic interneuron migration [ISS]

dopamine metabolic process [IC]

mating behavior [ISS]

phospholipase C-activating dopamine receptor signaling pathway [IDA, IGI]

positive regulation of cAMP biosynthetic process [IDA]

positive regulation of cell migration [ISS]

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [IDA]

positive regulation of potassium ion transport [ISS]

positive regulation of release of sequestered calcium ion into cytosol [IDA]

positive regulation of synaptic transmission, glutamatergic [ISS]

prepulse inhibition [ISS]

regulation of dopamine uptake involved in synaptic transmission [IC]

response to drug [ISS]

synapse assembly [ISS]

transmission of nerve impulse [ISS]

visual learning [ISS]

Gene Ontology Molecular Function

dopamine binding [IMP]
dopamine neurotransmitter receptor activity [IDA]
dopamine neurotransmitter receptor activity, coupled via Gs [IDA, IMP]
protein binding [IPI]

Gene Ontology Cellular Component

integral component of plasma membrane [IC]

plasma membrane [IDA, TAS]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Publication

Dopamine D1 and adenosine A1 receptors form functionally interacting heteromeric complexes.

Gines S, Hillion J, Torvinen M, Le Crom S, Casado V, Canela EI, Rondin S, Lew JY, Watson S, Zoli M, Agnati LF, Verniera P, Lluis C, Ferre S, Fuxe K, Franco R

The possible molecular basis for the previously described antagonistic interactions between adenosine A(1) receptors (A(1)R) and dopamine D(1) receptors (D(1)R) in the brain have been studied in mouse fibroblast Ltk(-) cells cotransfected with human A(1)R and D(1)R cDNAs or with human A(1)R and dopamine D(2) receptor (long-form) (D(2)R) cDNAs and in cortical neurons in culture. A(1)R and D(1)R, but not ... [more]

Proc. Natl. Acad. Sci. U.S.A. Jul. 18, 2000; 97(15);8606-11 [Pubmed: 10890919]

Throughput

Low Throughput

Curated By

BioGRID