GRM7
Gene Ontology Biological Process
- adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway [IDA, ISO]
- adult behavior [ISO]
- associative learning [ISO]
- behavioral fear response [ISO]
- calcium ion transmembrane transport [ISO]
- conditioned taste aversion [ISO]
- learning or memory [TAS]
- memory [ISO]
- multicellular organismal response to stress [ISO]
- negative regulation of adenylate cyclase activity [ISO]
- negative regulation of cAMP biosynthetic process [ISO]
- negative regulation of glutamate secretion [IDA]
- neurological system process [ISO]
- regulation of cyclase activity [ISO]
- regulation of ion transmembrane transport [ISO]
- regulation of synaptic transmission, glutamatergic [IBA]
- sensory perception of sound [ISO]
- short-term memory [ISO]
- synaptic transmission [ISO]
- transmission of nerve impulse [ISO]
Gene Ontology Molecular Function- PDZ domain binding [IPI]
- adenylate cyclase inhibiting G-protein coupled glutamate receptor activity [IDA]
- adenylate cyclase inhibitor activity [ISO]
- calcium channel regulator activity [IBA, ISO]
- calcium ion binding [ISO]
- calcium-dependent protein binding [IPI]
- calmodulin binding [IPI]
- glutamate binding [IDA, ISO]
- glutamate receptor activity [ISO]
- group III metabotropic glutamate receptor activity [IDA, ISO, TAS]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- serine binding [ISO]
- voltage-gated calcium channel activity [ISO]
- PDZ domain binding [IPI]
- adenylate cyclase inhibiting G-protein coupled glutamate receptor activity [IDA]
- adenylate cyclase inhibitor activity [ISO]
- calcium channel regulator activity [IBA, ISO]
- calcium ion binding [ISO]
- calcium-dependent protein binding [IPI]
- calmodulin binding [IPI]
- glutamate binding [IDA, ISO]
- glutamate receptor activity [ISO]
- group III metabotropic glutamate receptor activity [IDA, ISO, TAS]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- serine binding [ISO]
- voltage-gated calcium channel activity [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- asymmetric synapse [IDA]
- axon [IDA]
- axon terminus [IDA]
- cell cortex [ISO]
- cell surface [IDA]
- dendrite [IDA, ISO]
- dendritic shaft [IDA]
- integral component of membrane [ISO]
- integral component of plasma membrane [IBA]
- membrane [IDA]
- neuronal cell body [IDA]
- postsynaptic membrane [IDA]
- presynaptic active zone [IDA]
- presynaptic membrane [IDA, ISO]
- protein complex [IDA]
- receptor complex [ISO]
- rough endoplasmic reticulum [IDA]
- synapse [IDA]
- terminal bouton [IDA]
FLNA
Gene Ontology Biological Process
- actin crosslink formation [IDA]
- actin cytoskeleton reorganization [IDA]
- adenylate cyclase-inhibiting dopamine receptor signaling pathway [IMP]
- blood coagulation [TAS]
- cell junction assembly [TAS]
- cilium assembly [IMP]
- cytoplasmic sequestering of protein [IMP]
- establishment of protein localization [IDA]
- negative regulation of protein catabolic process [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- platelet activation [TAS]
- platelet aggregation [IMP]
- platelet degranulation [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- positive regulation of transcription factor import into nucleus [IMP]
- protein localization to cell surface [IDA]
- protein stabilization [IMP]
- receptor clustering [IDA]
- spindle assembly involved in mitosis [IDA]
Gene Ontology Molecular Function- Fc-gamma receptor I complex binding [IDA]
- Rac GTPase binding [IDA]
- Ral GTPase binding [IDA]
- Rho GTPase binding [IDA]
- actin filament binding [IDA]
- glycoprotein binding [IDA]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- signal transducer activity [IMP]
- small GTPase binding [IDA]
- transcription factor binding [IPI]
- Fc-gamma receptor I complex binding [IDA]
- Rac GTPase binding [IDA]
- Ral GTPase binding [IDA]
- Rho GTPase binding [IDA]
- actin filament binding [IDA]
- glycoprotein binding [IDA]
- poly(A) RNA binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- signal transducer activity [IMP]
- small GTPase binding [IDA]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7.
A yeast two-hybrid screen identified Filamin-A as a binding partner of the metabotropic glutamate receptor type 7b (mGluR7b) splice variant. In addition, Filamin-A interacted with mGluR4a, mGluR5a, mGluR5b, mGluR7a and mGluR8a. Domain mapping revealed that alternative splicing of mGluR4, mGluR7 and mGluR8 C-termini regulated the interaction. A conserved tyrosine within mGluR C-termini was identified to mediate the binding to Filamin-A. ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID