ENG
Gene Ontology Biological Process
- BMP signaling pathway [TAS]
- artery morphogenesis [ISS]
- cell chemotaxis [IMP]
- cell migration [IMP]
- cell motility [IMP]
- central nervous system vasculogenesis [IMP]
- chronological cell aging [IEP]
- detection of hypoxia [IDA]
- extracellular matrix disassembly [IMP]
- heart looping [ISS]
- intracellular signal transduction [IDA]
- negative regulation of cell migration [IDA]
- negative regulation of endothelial cell proliferation [IMP]
- negative regulation of nitric-oxide synthase activity [IMP]
- negative regulation of pathway-restricted SMAD protein phosphorylation [IMP]
- negative regulation of protein autophosphorylation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- patterning of blood vessels [ISS]
- positive regulation of BMP signaling pathway [IDA]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IDA, IMP]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of systemic arterial blood pressure [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of cell adhesion [TAS]
- regulation of cell proliferation [TAS]
- regulation of phosphorylation [TAS]
- regulation of transcription, DNA-templated [IMP]
- regulation of transforming growth factor beta receptor signaling pathway [IDA]
- response to hypoxia [IDA]
- smooth muscle tissue development [ISS]
- transforming growth factor beta receptor signaling pathway [IDA]
- vasculogenesis [IMP]
- venous blood vessel morphogenesis [ISS]
- wound healing [IMP]
Gene Ontology Molecular Function- activin binding [TAS]
- galactose binding [IDA]
- glycosaminoglycan binding [IDA, ISS]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- transforming growth factor beta binding [IPI]
- transforming growth factor beta receptor, cytoplasmic mediator activity [IDA]
- transforming growth factor beta-activated receptor activity [IDA]
- transmembrane signaling receptor activity [NAS]
- type I transforming growth factor beta receptor binding [IPI, ISS]
- type II transforming growth factor beta receptor binding [IPI, ISS]
- activin binding [TAS]
- galactose binding [IDA]
- glycosaminoglycan binding [IDA, ISS]
- protein binding [IPI]
- protein homodimerization activity [IPI]
- transforming growth factor beta binding [IPI]
- transforming growth factor beta receptor, cytoplasmic mediator activity [IDA]
- transforming growth factor beta-activated receptor activity [IDA]
- transmembrane signaling receptor activity [NAS]
- type I transforming growth factor beta receptor binding [IPI, ISS]
- type II transforming growth factor beta receptor binding [IPI, ISS]
Gene Ontology Cellular Component
ACVR2B
Gene Ontology Biological Process
- BMP signaling pathway [IDA, IMP, TAS]
- activin receptor signaling pathway [TAS]
- anterior/posterior pattern specification [IMP]
- artery development [ISS]
- blood vessel remodeling [ISS]
- lymphangiogenesis [ISS]
- lymphatic endothelial cell differentiation [ISS]
- positive regulation of activin receptor signaling pathway [IDA]
- positive regulation of bone mineralization [IMP]
- positive regulation of osteoblast differentiation [IMP]
- regulation of transcription, DNA-templated [IDA]
- retina vasculature development in camera-type eye [ISS]
- signal transduction [IDA]
- transmembrane receptor protein serine/threonine kinase signaling pathway [TAS]
- venous blood vessel development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily.
Endoglin (CD105) is a transmembrane glycoprotein that binds transforming growth factor (TGF)-beta1 and -beta3, and coprecipitates with the Ser/Thr kinase signaling receptor complex by affinity labeling of endothelial and leukemic cells. The present study shows that in addition to TGF-beta1 and -beta3, endoglin interacts with activin-A, bone morphogenetic protein (BMP)-7, and BMP-2 but requires coexpression of the respective ligand binding ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID