BAIT

GRIN2A

EPND, FESD, GluN2A, LKS, NMDAR2A, NR2A, RP11-297M9.2
glutamate receptor, ionotropic, N-methyl D-aspartate 2A
Alzheimer's Disease Project
Glioblastoma Project
Homo sapiens
PREY

DLG2

PPP1R58, PSD-93, PSD93, chapsyn-110
discs, large homolog 2 (Drosophila)
GO Process (2)
GO Function (2)
GO Component (4)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Binding of neuroligins to PSD-95.

Irie M, Hata Y, Takeuchi M, Ichtchenko K, Toyoda A, Hirao K, Takai Y, Rosahl TW, Suedhof TC

PSD-95 is a component of postsynaptic densities in central synapses. It contains three PDZ domains that localize N-methyl-D-aspartate receptor subunit 2 (NMDA2 receptor) and K+ channels to synapses. In mouse forebrain, PSD-95 bound to the cytoplasmic COOH-termini of neuroligins, which are neuronal cell adhesion molecules that interact with beta-neurexins and form intercellular junctions. Neuroligins bind to the third PDZ domain ... [more]

Science Sep. 05, 1997; 277(5331);1511-5 [Pubmed: 9278515]

Throughput

  • Low Throughput

Curated By

  • BioGRID