CNTFR
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CLCF1
Gene Ontology Biological Process
- B cell differentiation [ISS]
- JAK-STAT cascade [ISS]
- cell surface receptor signaling pathway [ISS]
- cytokine-mediated signaling pathway [NAS]
- negative regulation of neuron apoptotic process [IDA]
- positive regulation of B cell proliferation [ISS]
- positive regulation of astrocyte differentiation [ISS]
- positive regulation of cell proliferation [IDA]
- positive regulation of immunoglobulin production [ISS]
- positive regulation of isotype switching to IgE isotypes [ISS]
- positive regulation of tyrosine phosphorylation of Stat3 protein [IDA, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-purification
An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps.
Publication
The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine.
Ciliary neurotrophic factor (CNTF) is involved in the survival of a number of different neural cell types, including motor neurons. CNTF functional responses are mediated through a tripartite membrane receptor composed of two signalling receptor chains, gp130 and the leukaemia inhibitory factor receptor (LIFR), associated with a non-signalling CNTF binding receptor alpha component (CNTFR). CNTFR-deficient mice show profound neuronal deficits ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CNTFR CLCF1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID