BAIT
SMC3
BAM, BMH, CDLS3, CSPG6, HCAP, SMC3L1
structural maintenance of chromosomes 3
GO Process (8)
GO Function (4)
GO Component (12)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RORA
NR1F1, ROR1, ROR2, ROR3, RZR-ALPHA, RZRA
RAR-related orphan receptor A
GO Process (25)
GO Function (10)
GO Component (2)
Gene Ontology Biological Process
- T-helper 17 cell differentiation [ISS]
- angiogenesis [IMP]
- cellular response to hypoxia [IMP]
- cellular response to sterol [IDA, IMP]
- cerebellar granule cell precursor proliferation [ISS]
- circadian regulation of gene expression [ISS]
- gene expression [TAS]
- intracellular receptor signaling pathway [IDA]
- muscle cell differentiation [IMP]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- negative regulation of fat cell differentiation [ISS]
- negative regulation of inflammatory response [IMP]
- positive regulation of circadian rhythm [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation vascular endothelial growth factor production [IMP]
- regulation of cholesterol homeostasis [ISS]
- regulation of glucose metabolic process [ISS]
- regulation of smoothened signaling pathway [ISS]
- regulation of steroid metabolic process [ISS]
- regulation of transcription involved in cell fate commitment [ISS]
- regulation of transcription, DNA-templated [IDA]
- transcription initiation from RNA polymerase II promoter [TAS]
- triglyceride homeostasis [IMP]
- xenobiotic metabolic process [ISS]
Gene Ontology Molecular Function- DNA binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- direct ligand regulated sequence-specific DNA binding transcription factor activity [IDA]
- oxysterol binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator binding [IPI]
- transcription corepressor binding [IPI]
- transcription factor binding [IPI]
- DNA binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- direct ligand regulated sequence-specific DNA binding transcription factor activity [IDA]
- oxysterol binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription coactivator binding [IPI]
- transcription corepressor binding [IPI]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
- nucleoplasm [TAS]
- nucleus [IDA]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.
The cohesin complex regulates sister chromatid cohesion, chromosome organization, gene expression, and DNA repair. Cohesin is a ring complex composed of four core subunits and seven regulatory subunits. In an effort to comprehensively identify additional cohesin-interacting proteins, we used gene editing to introduce a dual epitope tag into the endogenous allele of each of 11 known components of cohesin in ... [more]
J. Biol. Chem. Dec. 31, 2018; 294(22);8760-8772 [Pubmed: 31010829]
Throughput
- High Throughput
Curated By
- BioGRID