BAIT
LRP1
A2MR, APOER, APR, CD91, IGFBP3R, LRP, LRP1A, TGFBR5
low density lipoprotein receptor-related protein 1
GO Process (14)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- aorta morphogenesis [ISS]
- apoptotic cell clearance [ISS]
- beta-amyloid clearance [TAS]
- lipoprotein transport [NAS]
- negative regulation of Wnt signaling pathway [ISS]
- negative regulation of platelet-derived growth factor receptor-beta signaling pathway [ISS]
- negative regulation of smooth muscle cell migration [ISS]
- phototransduction, visible light [TAS]
- positive regulation of cholesterol efflux [ISS]
- positive regulation of lipid transport [ISS]
- regulation of actin cytoskeleton organization [ISS]
- regulation of cholesterol transport [ISS]
- regulation of phospholipase A2 activity [ISS]
- retinoid metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NGF
Beta-NGF, HSAN5, NGFB
nerve growth factor (beta polypeptide)
GO Process (21)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- Ras protein signal transduction [TAS]
- activation of MAPKK activity [TAS]
- activation of phospholipase C activity [TAS]
- apoptotic signaling pathway [TAS]
- cell-cell signaling [IBA]
- extrinsic apoptotic signaling pathway via death domain receptors [IDA]
- negative regulation of apoptotic process [TAS]
- negative regulation of cell cycle [TAS]
- negative regulation of neuron apoptotic process [IBA]
- nerve growth factor processing [TAS]
- neuron projection morphogenesis [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of apoptotic process [TAS]
- positive regulation of axonogenesis [TAS]
- positive regulation of gene expression [IMP]
- regulation of axonogenesis [TAS]
- regulation of cysteine-type endopeptidase activity involved in apoptotic process [TAS]
- regulation of neuron differentiation [IBA]
- small GTPase mediated signal transduction [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Neurotrophin binding to human alpha 2-macroglobulin under apparent equilibrium conditions.
alpha 2-Macroglobulin (alpha 2M) is a broad-spectrum proteinase inhibitor and a carrier of certain growth factors. The purpose of this investigation was to characterize the interaction of alpha 2M with nerve growth factor-beta (NGF-beta), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), neurotrophin-4 (NT-4), and ciliary neurotrophic factor (CNTF) under apparent equilibrium conditions. Binding in solution was assessed using the cross-linking agent ... [more]
Biochemistry Sep. 20, 1994; 33(37);11270-7 [Pubmed: 7537086]
Throughput
- Low Throughput
Curated By
- BioGRID