BAIT
CAPN3
CANP3, CANPL3, LGMD2, LGMD2A, nCL-1, p94
calpain 3, (p94)
GO Process (25)
GO Function (12)
GO Component (9)
Gene Ontology Biological Process
- apoptotic process [TAS]
- cellular response to calcium ion [ISS]
- cellular response to salt stress [ISS]
- muscle cell cellular homeostasis [TAS]
- muscle organ development [TAS]
- muscle structure development [ISS]
- myofibril assembly [ISS, TAS]
- negative regulation of apoptotic process [IMP]
- negative regulation of protein sumoylation [IDA]
- negative regulation of transcription, DNA-templated [ISS]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of proteolysis [ISS]
- positive regulation of release of sequestered calcium ion into cytosol [ISS]
- positive regulation of satellite cell activation involved in skeletal muscle regeneration [ISS]
- positive regulation of transcription, DNA-templated [IMP]
- protein complex assembly [ISS]
- protein localization to membrane [ISS]
- proteolysis [IDA]
- regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- regulation of catalytic activity [IDA]
- response to calcium ion [ISS]
- response to muscle activity [ISS]
- sarcomere organization [ISS]
- self proteolysis [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function- calcium ion binding [ISS]
- calcium-dependent cysteine-type endopeptidase activity [IBA, ISS, TAS]
- catalytic activity [IDA]
- cysteine-type peptidase activity [TAS]
- ligase regulator activity [IDA]
- peptidase activity [IDA]
- protein binding [IPI]
- protein complex scaffold [ISS]
- signal transducer activity [TAS]
- sodium ion binding [ISS]
- structural constituent of muscle [ISS]
- titin binding [IPI]
- calcium ion binding [ISS]
- calcium-dependent cysteine-type endopeptidase activity [IBA, ISS, TAS]
- catalytic activity [IDA]
- cysteine-type peptidase activity [TAS]
- ligase regulator activity [IDA]
- peptidase activity [IDA]
- protein binding [IPI]
- protein complex scaffold [ISS]
- signal transducer activity [TAS]
- sodium ion binding [ISS]
- structural constituent of muscle [ISS]
- titin binding [IPI]
Homo sapiens
PREY
MYBPC1
LCCS4, MYBPCC, MYBPCS
myosin binding protein C, slow type
GO Process (1)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.
The complexity of the skeletal muscle and the identification of numerous human disease-causing mutations in its constitutive proteins make it an interesting tissue for proteomic studies aimed at understanding functional relationships of interacting proteins in both health and diseases.We undertook a large-scale study using two-hybrid screens and a human skeletal-muscle cDNA library to establish a proteome-scale map of protein-protein interactions ... [more]
Skelet Muscle Feb. 19, 2013; 3(1);3 [Pubmed: 23414517]
Throughput
- High Throughput
Curated By
- BioGRID