CAPN3
Gene Ontology Biological Process
- apoptotic process [TAS]
- cellular response to calcium ion [ISS]
- cellular response to salt stress [ISS]
- muscle cell cellular homeostasis [TAS]
- muscle organ development [TAS]
- muscle structure development [ISS]
- myofibril assembly [ISS, TAS]
- negative regulation of apoptotic process [IMP]
- negative regulation of protein sumoylation [IDA]
- negative regulation of transcription, DNA-templated [ISS]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of proteolysis [ISS]
- positive regulation of release of sequestered calcium ion into cytosol [ISS]
- positive regulation of satellite cell activation involved in skeletal muscle regeneration [ISS]
- positive regulation of transcription, DNA-templated [IMP]
- protein complex assembly [ISS]
- protein localization to membrane [ISS]
- proteolysis [IDA]
- regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- regulation of catalytic activity [IDA]
- response to calcium ion [ISS]
- response to muscle activity [ISS]
- sarcomere organization [ISS]
- self proteolysis [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function- calcium ion binding [ISS]
- calcium-dependent cysteine-type endopeptidase activity [IBA, ISS, TAS]
- catalytic activity [IDA]
- cysteine-type peptidase activity [TAS]
- ligase regulator activity [IDA]
- peptidase activity [IDA]
- protein binding [IPI]
- protein complex scaffold [ISS]
- signal transducer activity [TAS]
- sodium ion binding [ISS]
- structural constituent of muscle [ISS]
- titin binding [IPI]
- calcium ion binding [ISS]
- calcium-dependent cysteine-type endopeptidase activity [IBA, ISS, TAS]
- catalytic activity [IDA]
- cysteine-type peptidase activity [TAS]
- ligase regulator activity [IDA]
- peptidase activity [IDA]
- protein binding [IPI]
- protein complex scaffold [ISS]
- signal transducer activity [TAS]
- sodium ion binding [ISS]
- structural constituent of muscle [ISS]
- titin binding [IPI]
TTN
Gene Ontology Biological Process
- blood coagulation [TAS]
- cardiac muscle contraction [IMP]
- cardiac muscle fiber development [IMP]
- cardiac muscle hypertrophy [IMP]
- cardiac muscle tissue morphogenesis [IMP]
- cardiac myofibril assembly [IMP]
- detection of muscle stretch [TAS]
- mitotic chromosome condensation [IEP]
- muscle contraction [NAS, TAS]
- muscle filament sliding [TAS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- regulation of catalytic activity [IMP]
- regulation of protein kinase activity [IMP]
- response to calcium ion [IDA]
- sarcomere organization [IMP]
- sarcomerogenesis [IMP]
- skeletal muscle myosin thick filament assembly [IMP]
- skeletal muscle thin filament assembly [IMP]
- striated muscle contraction [TAS]
Gene Ontology Molecular Function- actin filament binding [IDA]
- actinin binding [IDA, IPI]
- calcium ion binding [IDA]
- calmodulin binding [IPI, TAS]
- enzyme binding [IPI]
- identical protein binding [IPI]
- muscle alpha-actinin binding [IPI]
- protease binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein self-association [IDA]
- protein serine/threonine kinase activity [IDA]
- structural constituent of muscle [IMP, TAS]
- structural molecule activity conferring elasticity [TAS]
- telethonin binding [IPI, ISS]
- actin filament binding [IDA]
- actinin binding [IDA, IPI]
- calcium ion binding [IDA]
- calmodulin binding [IPI, TAS]
- enzyme binding [IPI]
- identical protein binding [IPI]
- muscle alpha-actinin binding [IPI]
- protease binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- protein self-association [IDA]
- protein serine/threonine kinase activity [IDA]
- structural constituent of muscle [IMP, TAS]
- structural molecule activity conferring elasticity [TAS]
- telethonin binding [IPI, ISS]
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.
The complexity of the skeletal muscle and the identification of numerous human disease-causing mutations in its constitutive proteins make it an interesting tissue for proteomic studies aimed at understanding functional relationships of interacting proteins in both health and diseases.We undertook a large-scale study using two-hybrid screens and a human skeletal-muscle cDNA library to establish a proteome-scale map of protein-protein interactions ... [more]
Throughput
- High Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
CAPN3 TTN | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - | |
CAPN3 TTN | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID