BAIT
CAPN3
CANP3, CANPL3, LGMD2, LGMD2A, nCL-1, p94
calpain 3, (p94)
GO Process (25)
GO Function (12)
GO Component (9)
Gene Ontology Biological Process
- apoptotic process [TAS]
- cellular response to calcium ion [ISS]
- cellular response to salt stress [ISS]
- muscle cell cellular homeostasis [TAS]
- muscle organ development [TAS]
- muscle structure development [ISS]
- myofibril assembly [ISS, TAS]
- negative regulation of apoptotic process [IMP]
- negative regulation of protein sumoylation [IDA]
- negative regulation of transcription, DNA-templated [ISS]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of proteolysis [ISS]
- positive regulation of release of sequestered calcium ion into cytosol [ISS]
- positive regulation of satellite cell activation involved in skeletal muscle regeneration [ISS]
- positive regulation of transcription, DNA-templated [IMP]
- protein complex assembly [ISS]
- protein localization to membrane [ISS]
- proteolysis [IDA]
- regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- regulation of catalytic activity [IDA]
- response to calcium ion [ISS]
- response to muscle activity [ISS]
- sarcomere organization [ISS]
- self proteolysis [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function- calcium ion binding [ISS]
- calcium-dependent cysteine-type endopeptidase activity [IBA, ISS, TAS]
- catalytic activity [IDA]
- cysteine-type peptidase activity [TAS]
- ligase regulator activity [IDA]
- peptidase activity [IDA]
- protein binding [IPI]
- protein complex scaffold [ISS]
- signal transducer activity [TAS]
- sodium ion binding [ISS]
- structural constituent of muscle [ISS]
- titin binding [IPI]
- calcium ion binding [ISS]
- calcium-dependent cysteine-type endopeptidase activity [IBA, ISS, TAS]
- catalytic activity [IDA]
- cysteine-type peptidase activity [TAS]
- ligase regulator activity [IDA]
- peptidase activity [IDA]
- protein binding [IPI]
- protein complex scaffold [ISS]
- signal transducer activity [TAS]
- sodium ion binding [ISS]
- structural constituent of muscle [ISS]
- titin binding [IPI]
Homo sapiens
PREY
PSMC3
TBP1
proteasome (prosome, macropain) 26S subunit, ATPase, 3
GO Process (24)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- ATP catabolic process [ISS]
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [TAS]
- G1/S transition of mitotic cell cycle [TAS]
- RNA metabolic process [TAS]
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- apoptotic process [TAS]
- cellular nitrogen compound metabolic process [TAS]
- gene expression [TAS]
- mRNA metabolic process [TAS]
- mitotic cell cycle [TAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of nucleic acid-templated transcription [TAS]
- negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- protein polyubiquitination [TAS]
- regulation of apoptotic process [TAS]
- regulation of cellular amino acid metabolic process [TAS]
- regulation of nucleic acid-templated transcription [TAS]
- regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]
- small molecule metabolic process [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.
The complexity of the skeletal muscle and the identification of numerous human disease-causing mutations in its constitutive proteins make it an interesting tissue for proteomic studies aimed at understanding functional relationships of interacting proteins in both health and diseases.We undertook a large-scale study using two-hybrid screens and a human skeletal-muscle cDNA library to establish a proteome-scale map of protein-protein interactions ... [more]
Skelet Muscle Feb. 19, 2013; 3(1);3 [Pubmed: 23414517]
Throughput
- High Throughput
Curated By
- BioGRID