BAIT
PCNA
ATLD2
proliferating cell nuclear antigen
GO Process (18)
GO Function (8)
GO Component (9)
Gene Ontology Biological Process
- DNA repair [TAS]
- DNA strand elongation involved in DNA replication [TAS]
- G1/S transition of mitotic cell cycle [TAS]
- base-excision repair [TAS]
- cell proliferation [TAS]
- epithelial cell differentiation [IEP]
- leading strand elongation [IBA]
- mismatch repair [IDA]
- mitotic cell cycle [TAS]
- nucleotide-excision repair [TAS]
- nucleotide-excision repair, DNA gap filling [TAS]
- positive regulation of deoxyribonuclease activity [IDA]
- regulation of transcription involved in G1/S transition of mitotic cell cycle [TAS]
- telomere maintenance [TAS]
- telomere maintenance via recombination [TAS]
- telomere maintenance via semi-conservative replication [TAS]
- transcription-coupled nucleotide-excision repair [TAS]
- translesion synthesis [IDA]
Gene Ontology Molecular Function- DNA polymerase binding [IPI]
- DNA polymerase processivity factor activity [IBA]
- MutLalpha complex binding [IDA]
- dinucleotide insertion or deletion binding [IDA]
- identical protein binding [IPI]
- protein binding [IPI]
- purine-specific mismatch base pair DNA N-glycosylase activity [IDA]
- receptor tyrosine kinase binding [IPI]
- DNA polymerase binding [IPI]
- DNA polymerase processivity factor activity [IBA]
- MutLalpha complex binding [IDA]
- dinucleotide insertion or deletion binding [IDA]
- identical protein binding [IPI]
- protein binding [IPI]
- purine-specific mismatch base pair DNA N-glycosylase activity [IDA]
- receptor tyrosine kinase binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
CDC6
CDC18L, HsCDC18, HsCDC6
cell division cycle 6
GO Process (12)
GO Function (3)
GO Component (7)
Gene Ontology Biological Process
- DNA replication [TAS]
- DNA replication checkpoint [TAS]
- G1/S transition of mitotic cell cycle [TAS]
- mitotic cell cycle [TAS]
- negative regulation of DNA replication [TAS]
- negative regulation of cell proliferation [TAS]
- positive regulation of chromosome segregation [IDA]
- positive regulation of cytokinesis [IMP]
- regulation of cyclin-dependent protein serine/threonine kinase activity [TAS]
- regulation of mitotic metaphase/anaphase transition [IMP]
- regulation of transcription involved in G1/S transition of mitotic cell cycle [TAS]
- traversing start control point of mitotic cell cycle [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase.
In a two-hybrid screen for proteins that interact with human PCNA, we identified and cloned a human protein (hCdc18) homologous to yeast CDC6/Cdc18 and human Orc1. Unlike yeast, in which the rapid and total destruction of CDC6/Cdc18 protein in S phase is a central feature of DNA replication, the total level of the human protein is unchanged throughout the cell ... [more]
Mol. Cell. Biol. May. 01, 1998; 18(5);2758-67 [Pubmed: 9566895]
Throughput
- Low Throughput
Curated By
- BioGRID