BAIT
TGFBR2
AAT3, FAA3, LDS1B, LDS2, LDS2B, MFS2, RIIC, TAAD2, TGFR-2, TGFbeta-RII
transforming growth factor, beta receptor II (70/80kDa)
GO Process (27)
GO Function (8)
GO Component (7)
Gene Ontology Biological Process
- activation of protein kinase activity [ISS]
- apoptotic process [IDA]
- blood vessel development [TAS]
- brain development [ISS]
- embryonic cranial skeleton morphogenesis [ISS]
- embryonic hemopoiesis [ISS]
- heart development [ISS]
- myeloid dendritic cell differentiation [ISS]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- palate development [ISS]
- pathway-restricted SMAD protein phosphorylation [IDA]
- patterning of blood vessels [ISS]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of B cell tolerance induction [ISS]
- positive regulation of NK T cell differentiation [ISS]
- positive regulation of T cell tolerance induction [ISS]
- positive regulation of cell proliferation [TAS]
- positive regulation of mesenchymal cell proliferation [ISS]
- positive regulation of reactive oxygen species metabolic process [IMP]
- positive regulation of tolerance induction to self antigen [ISS]
- protein phosphorylation [IDA]
- regulation of cell proliferation [ISS]
- response to cholesterol [IDA]
- response to drug [IDA]
- transforming growth factor beta receptor signaling pathway [IC, IDA, IMP, TAS]
- vasculogenesis [ISS]
Gene Ontology Molecular Function- SMAD binding [IDA]
- glycosaminoglycan binding [IDA]
- protein binding [IPI]
- transforming growth factor beta binding [IDA, IPI]
- transforming growth factor beta-activated receptor activity [IC, IDA, IMP]
- transmembrane receptor protein serine/threonine kinase activity [IDA]
- type I transforming growth factor beta receptor binding [IDA, IPI]
- type III transforming growth factor beta receptor binding [IDA]
- SMAD binding [IDA]
- glycosaminoglycan binding [IDA]
- protein binding [IPI]
- transforming growth factor beta binding [IDA, IPI]
- transforming growth factor beta-activated receptor activity [IC, IDA, IMP]
- transmembrane receptor protein serine/threonine kinase activity [IDA]
- type I transforming growth factor beta receptor binding [IDA, IPI]
- type III transforming growth factor beta receptor binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
FANCC
FA3, FAC, FACC, RP11-80I15.2
Fanconi anemia, complementation group C
GO Process (2)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Charting the molecular links between driver and susceptibility genes in colorectal cancer.
Despite significant advances in the identification of specific genes and pathways important in the onset and progression of colorectal cancer (CRC), mechanistic insight into the relationship between driver and susceptibility genes is needed. In this paper, we systematically explore physical interactions between causative and putative CRC susceptibility genes to reveal the molecular mechanisms involved in tumor biology. In total, we ... [more]
Unknown Mar. 21, 2014; 445(4);734-8 [Pubmed: 24412244]
Throughput
- High Throughput
Curated By
- BioGRID