BAIT
BMPR1A
10q23del, ACVRLK3, ALK3, CD292, SKR5
bone morphogenetic protein receptor, type IA
GO Process (9)
GO Function (6)
GO Component (2)
Gene Ontology Biological Process
- BMP signaling pathway [IDA, TAS]
- endocardial cushion formation [ISS]
- immune response [IMP]
- positive regulation of SMAD protein import into nucleus [IDA]
- positive regulation of bone mineralization [IMP]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IDA]
- protein phosphorylation [IDA]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- caveola [IMP]
- plasma membrane [IDA, TAS]
Homo sapiens
PREY
SFRP2
FRP-2, SARP1, SDF-5, FKSG12
secreted frizzled-related protein 2
GO Process (29)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- cardiac left ventricle morphogenesis [IMP]
- cell-cell signaling [ISS]
- hematopoietic stem cell proliferation [ISS]
- negative regulation of Wnt signaling pathway [IDA]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of cell growth [IDA]
- negative regulation of cell migration [ISS]
- negative regulation of cell proliferation [IDA, IMP]
- negative regulation of dermatome development [ISS]
- negative regulation of epithelial cell proliferation [IDA]
- negative regulation of epithelial to mesenchymal transition [IDA]
- negative regulation of gene expression [ISS]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [ISS]
- negative regulation of peptidyl-tyrosine phosphorylation [ISS]
- negative regulation of transcription, DNA-templated [IDA]
- non-canonical Wnt signaling pathway [IBA]
- outflow tract morphogenesis [IMP]
- patterning of blood vessels [ISS]
- positive regulation of angiogenesis [ISS]
- positive regulation of apoptotic process [IMP]
- positive regulation of canonical Wnt signaling pathway [ISS]
- positive regulation of cell adhesion mediated by integrin [ISS]
- positive regulation of cell growth [ISS]
- positive regulation of cell proliferation [IDA]
- positive regulation of fat cell differentiation [IDA]
- positive regulation of peptidyl-serine phosphorylation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- regulation of stem cell division [ISS]
- sclerotome development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Charting the molecular links between driver and susceptibility genes in colorectal cancer.
Despite significant advances in the identification of specific genes and pathways important in the onset and progression of colorectal cancer (CRC), mechanistic insight into the relationship between driver and susceptibility genes is needed. In this paper, we systematically explore physical interactions between causative and putative CRC susceptibility genes to reveal the molecular mechanisms involved in tumor biology. In total, we ... [more]
Unknown Mar. 21, 2014; 445(4);734-8 [Pubmed: 24412244]
Throughput
- High Throughput
Curated By
- BioGRID